Evolutionary Analysis (5th Edition)
5th Edition
ISBN: 9780321616678
Author: Jon C. Herron, Scott Freeman
Publisher: PEARSON
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Chapter 1, Problem 12Q
Not all viruses are dangerous. (The common cold is an example.) HIV, however, is nearly 100% lethal. Describe three major hypotheses for why HIV is so highly lethal.
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a. What percentage of a drug is eliminated after 4 half-lives? Please round to the nearest percent.
b. What will happen to elimination of the drug in the previous question if the system is saturated? explain and show any math involved
If you wanted to reduce the difference between peak and trough levels that occur with repeated administration of a drug, how would you adjust the dose and dose interval without changing the plateau concentration (plateau is the average of peak and trough levels)? Select your answers for both dose and interval. Hint: It may be helpful to think about this problem using an example such as food. How would you eat if you wanted to maintain very steady hunger/satiety levels without changing your total caloric intake?
Options:
A. Dose; Increase dose
B. Dose; Decrease dose
C. Dose; Do not change dose
D. Interval; Increase the interval between doses (give the drug less frequently)
E. Interval; Decrease the interval between doses (give the drug more frequently)
F. Interval; Do not change the interval
What percentage of a drug is eliminated after 4 half-lives? Please round to the nearest percent. Show the math
Chapter 1 Solutions
Evolutionary Analysis (5th Edition)
Ch. 1 - Prob. 1QCh. 1 - Prob. 2QCh. 1 - Prob. 3QCh. 1 - Given the risk of evolution of resistance, why do...Ch. 1 - Prob. 5QCh. 1 - Prob. 6QCh. 1 - In a monograph published in 1883, Alexander Graham...Ch. 1 - Design a study to test our prediction that human...Ch. 1 - Prob. 9QCh. 1 - Suppose that HIV were the ancestor of the SIVs,...
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