You extract the receptor binding domain protein and on testing, you realzie it does not elicit a strong immune response. Studies have shown that making slight alterations in the protein structure can elicit a stronger immune repsonse. You decide to take the route of genome editing in order to make these changes. Define "genome editing" and briefly explain how it can result in altering the receptor binding domain protein

You extract the receptor binding domain protein and on testing, you realzie it does not elicit a strong immune response. Studies have shown that making slight alterations in the protein structure can elicit a stronger immune repsonse. You decide to take the route of genome editing in order to make these changes. Define "genome editing" and briefly explain how it can result in altering the receptor binding domain protein

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter17: Genes And The Immune System

Section: Chapter Questions

Problem 13QP: The Adaptive Immune Response Is a Specific Defense Against Infection In cystic fibrosis gene...

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The Adaptive Immune Response Is a Specific Defense Against Infection In cystic fibrosis gene therapy, scientists propose the use of viral vectors to deliver normal genes to cells in the lungs. What immunological risks are involved in this procedure?
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Describes a method known as Western blotting that can be used to detect a polypeptide that is translated from a particular mRNA. In this method, a particular polypeptide or protein is detected by an antibody that specifically recognizes a segment of its amino acid sequence. After the antibody binds to the polypeptide within a gel, a secondary antibody (which is labeled) is used to visualize the polypeptide as a dark band.For example, an antibody that recognizes α-galactosidase A couldbe used to specifically detect the amount of α-galactosidase A proteinon a gel. The enzyme α-galactosidase A is defective in individuals with Fabry disease, which shows an X-linked recessive pattern of inheritance. Amy, Nan, and Pete are siblings, and Pete has Fabry disease. Aileen, Jason, and Jerry are brothers and sister, and Jerry has Fabry disease. Amy, Nan, and Pete are not related to Aileen, Jason, and Jerry. Amy, Nan, and Aileen are concerned that they could be carriers of a defective…
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In selecting target cells to receive a transferred gene in gene therapy, what factors do you think would have to be taken into account?
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