You are studying a human cancer cell line and you notice that you see the normal amount of RNA but the protein concentration is extremely low. When you investigate more closely you notice that the MRNA is properly processed and in the cytosol but you detect very little protein. When you sequence the mRNA you see no mutations. a) When you sequence the ribosomal RNA associated with the small subunit you notice two transition mutations. What function of the ribosome might be disrupted by these mutations? b) You also sequence the DNA encoding the large ribosomal subunit and notice one substitution mutation. What function of the ribosome might be disrupted by this mutation?

Human Anatomy & Physiology (11th Edition)
11th Edition
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Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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You are studying a human cancer cell line and you notice that you see the normal amount of
RNA but the protein concentration is extremely low. When you investigate more closely you
notice that the MRNA is properly processed and in the cytosol but you detect very little protein.
When you sequence the mRNA you see no mutations.
a) When you sequence the ribosomal RNA associated with the small subunit you notice
two transition mutations. What function of the ribosome might be disrupted by these
mutations?
b) You also sequence the DNA encoding the large ribosomal subunit and notice one
substitution mutation. What function of the ribosome might be disrupted by this
mutation?
c) Suggest one experiment that you might do to determine if the mutations in (a) or the
mutation in (b) is the cause of low protein production.
Transcribed Image Text:You are studying a human cancer cell line and you notice that you see the normal amount of RNA but the protein concentration is extremely low. When you investigate more closely you notice that the MRNA is properly processed and in the cytosol but you detect very little protein. When you sequence the mRNA you see no mutations. a) When you sequence the ribosomal RNA associated with the small subunit you notice two transition mutations. What function of the ribosome might be disrupted by these mutations? b) You also sequence the DNA encoding the large ribosomal subunit and notice one substitution mutation. What function of the ribosome might be disrupted by this mutation? c) Suggest one experiment that you might do to determine if the mutations in (a) or the mutation in (b) is the cause of low protein production.
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