Which of the following statements is false concerning T-cell development? a. γ and δ rearrangements may occur at two different stages, once at the committed double-negative stage and again at the uncommitted double-positive stage. b. If α-chain rearrangement is successful, it is still possible to produce a committed γ:δ T cell. c. Neither γ nor δ chains associate with pTα. d. T-cell development is biased in favor of α:β lineage commitment. e. A maximum of four attempts can be made to produce a functional β chain because there are two Cβ genes and associated Dβ and Jβ segments per β-chain locus. f. γ:δ T cells are not subject to positive or negative selection processes in the thymus.
Which of the following statements is false concerning T-cell development? a. γ and δ rearrangements may occur at two different stages, once at the committed double-negative stage and again at the uncommitted double-positive stage. b. If α-chain rearrangement is successful, it is still possible to produce a committed γ:δ T cell. c. Neither γ nor δ chains associate with pTα. d. T-cell development is biased in favor of α:β lineage commitment. e. A maximum of four attempts can be made to produce a functional β chain because there are two Cβ genes and associated Dβ and Jβ segments per β-chain locus. f. γ:δ T cells are not subject to positive or negative selection processes in the thymus.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Question
| Which of the following statements is false concerning T-cell development? |
|
a. γ and δ rearrangements may occur at two different stages, once at the committed double-negative stage and again at the uncommitted double-positive stage.
|
| b. If α-chain rearrangement is successful, it is still possible to produce a committed γ:δ T cell. |
| c. Neither γ nor δ chains associate with pTα. |
| d. T-cell development is biased in favor of α:β lineage commitment. |
|
e. A maximum of four attempts can be made to produce a functional β chain because there are two Cβ genes and associated Dβ and Jβ segments per β-chain locus.
|
| f. γ:δ T cells are not subject to positive or negative selection processes in the thymus. |
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