Which of the following is CORRECT?A) Pyruvate kinase requires Mg2+ for maximal activity.B) A small change of ATP concentrations within a cell leads to large changes ofAMP concentrations.C) A reduction of ATP concentrations will ultimately raise pyruvate kinaseactivity.D) All of the above.E) None of the above.

Pyruvate Kinase is an enzyme which catalyzes the last step of glycolysis, i.e. conversion of…

Answered: Which of the following is CORRECT? A)…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Signaling by tyrosine kinase receptors is generally associated with all of the following except: A) receptor dimerization B) growth factor responses C) heterotrimeric G proteins D) cross phosphorylation E) generating protein binding sites due to phosphorylation
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The authors in the abstract given above describe the mechanism for the activation of metallothionein (MTF) that results in the detoxification of heavy metals. Use a diagram to illustrate and describe the cascade of events that occur as proposed by the authors. Induction of metallothionein (MT) expression is involved in metal homeostasis and detoxification. To identify the key pathways that regulate metal-induced cytotoxicity, we investigate how phosphorylated metal-responsive transcription factor-1 (MTF-1) contributed to induction of MT expression. Immortal human embryonic kidney cells (HEK cells) were treated with seven kinds of metals including cadmium chloride (CdCl2), zinc sulphate (ZnSO4), copper sulphate (CuSO4), lead acetate (PbAc), nickel sulphate (NiSO4), sodium arsenite (NaAsO2), and potassium bichromate (K2Cr2O7). The MT expression was induced in a dose-response and time-dependent manner upon various metal treatments. A cycle of phosphorylation and dephosphorylation was…
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In a rare inherited disorder, called Wilson’s disease, excessive amounts of copper accumulate in liver and brain tissue. A prominent symptom of the disease is the deposition of copper in greenishbrown layers surrounding the cornea, called Kayser–Fleischer rings. A defective ATP-dependent protein that transports copper across cell membranes causes Wilson’s disease. Apparently, the copper transport protein is required to incorporate copper into ceruloplasmin and to excrete excess copper. In addition to a diet low in copper, Wilson’s disease is treated with zinc sulfate and the chelating agent penicillamine (p. 148). Describe how these treatments work. [Hint: Metallothionein has a greater affinity for copper than for zinc.]
For each of the following examples, indicate whether the drug is acting on physical process, chemical process or enzymatic system (your answer should be only; Physical, Chemical or Enzymatic). A. A drug is used as an antidote in lead poisoning and acts by binding to lead particles in body (chelation therapy). B. A drug acts to reduce flatulence and acts by reducing the surface tension of intestinal gas bubbles in the GI tract (e.g. Simethicone). C. A drug competes with alpha-glucosidase in intestine to reduce glucose conversion from disaccharides (e.g. Acarbose).
Q44
61. Degradation of glycogen in muscle fails to supply significant amounts of blood glucose because muscle lacks which of the following enzymes? A) Glucose-6-phosphatase B) Glucose-6-phosphate dehydrogenase C) Glycogen phosphorylase D) Phosphoglucomutase E) Phosphorylase kinase
Which of the following is NOT true of Complex 1? a.) it's a proton pump and it pumps 4H+ into the intermembrane space for every pair of electrons donated by NADH. b.) electrons from NADH are accepted by an FMN prosthetic group within Complex I. c.) electrons from NADH are passed through Complex 1 prosthetic groups to ubiquinone. d.) it accepts electrons from either NADH or FADH2

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