Under the stated conditions, the majority of the protein molecules in solution would be
Under the stated conditions, the majority of the protein molecules in solution would be
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
Related questions
Question
I’m having hard time if this protein is folded or unfolded can you please help?

Transcribed Image Text:Under the stated conditions, the majority of the protein molecules in
solution would be
O in a roughly-equal mixture of unfolded and folded states.
O unfolded.
folded.
O in an indeterminate mixture of folded and unfolded states.

Transcribed Image Text:Protein folding
Consider the equilibrium between the unfolded and folded (native) states
of a protein, shown below:
unfolded, inactive;
collection of many,
many "random"
structures
folded, native,
active 3-dimensional
structure of protein
folding (or
renaturation)
unfolding (or
denaturation)
For the reaction written as shown (folding direction), for this protein
under certain solution conditions at 25 "C:
AH'fe
=-25.1 kJ/mol
folding
AS'
folding =-0.06 kJ / (mol K).
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