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Need help on questions 3 and 4, please. Drop-down answer choices are images. Canine Scott Syndrome (CSS) is caused by a mutation in the splicing consensus motif in the TMEM16F gene. This mutation causes abnormal bleeding in the affected dogs.

Need help on questions 3 and 4, please. Drop-down answer choices are images. Canine Scott Syndrome (CSS) is caused by a mutation in the splicing consensus motif in the TMEM16F gene. This mutation causes abnormal bleeding in the affected dogs.

Human Heredity: Principles and Issues (MindTap Course List)
Human Heredity: Principles and Issues (MindTap Course List)
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ISBN:9781305251052
Author:Michael Cummings
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Chapter9: Gene Expression And Gene Regulation
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Problem 10QP: The pre-mRNA transcript and protein made by several mutant genes were examined. The results are...
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Need help on questions 3 and 4, please. Drop-down answer choices are images.

Canine Scott Syndrome (CSS) is caused by a mutation in the splicing consensus motif in the TMEM16F gene. This mutation causes abnormal bleeding in the affected dogs.

iii) What does the mutation do to the TMEM16F protein? 

iv) What does the wild-type TMEM16F enzyme do that is required to stop bleeding? 

 

iv) What does the wild-type TMEM16F enzyme do that is required to stop bleeding? switch phosphatidylserine from the internal leaflet to the external leaflet of the lipid bilayer in activated cells switch phosphatidylserine from the external leaflet to the internal leaflet of the lipid bilayer in activated cells switch phosphatidylcholine from the internal leaflet to the external leaflet of the lipid bilayer in activated cells switch phosphatidylcholine from the internal leaflet of to the external leaflet of the lipid bilayer constitutively switch phosphatidylserine from the internal leaflet to the external leaflet of the lipid bilayer constitutively switch phosphatidylserine from the external leaflet to the internal leaflet of the lipid bilayer constitutively
Transcribed Image Text:iv) What does the wild-type TMEM16F enzyme do that is required to stop bleeding? switch phosphatidylserine from the internal leaflet to the external leaflet of the lipid bilayer in activated cells switch phosphatidylserine from the external leaflet to the internal leaflet of the lipid bilayer in activated cells switch phosphatidylcholine from the internal leaflet to the external leaflet of the lipid bilayer in activated cells switch phosphatidylcholine from the internal leaflet of to the external leaflet of the lipid bilayer constitutively switch phosphatidylserine from the internal leaflet to the external leaflet of the lipid bilayer constitutively switch phosphatidylserine from the external leaflet to the internal leaflet of the lipid bilayer constitutively
iii) What does the mutation do to the TMEM16F protein? splicing is unaffected, truncated protein that doesn't fold correctly and is degraded splicing is affected, longer protein that retains normal enzymatic activity splicing is unaffected, frameshift mutation, and truncated protein that is degraded splicing is affected, frameshift mutation and protein is degraded splicing is affected, frameshift mutation, protein that is secreted splicing is affected, frameshift mutation, protein has more enzymatic activity
Transcribed Image Text:iii) What does the mutation do to the TMEM16F protein? splicing is unaffected, truncated protein that doesn't fold correctly and is degraded splicing is affected, longer protein that retains normal enzymatic activity splicing is unaffected, frameshift mutation, and truncated protein that is degraded splicing is affected, frameshift mutation and protein is degraded splicing is affected, frameshift mutation, protein that is secreted splicing is affected, frameshift mutation, protein has more enzymatic activity
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