I need help with both questions, please! Sigmas is the stationary phase sigma factor. Which of the following is a likely site for RNAP-Sigmasholoenzyme binding?The terminator region of genes involved in starvation stress responseThe -10 and -35 promoter regions of ribosomal RNA genesThe -10 and -35 promoter regions of genes involved in acid stress responseThe Shine-Delgarno sequence of genes involved in oxidative stress responseThe CAP operator of the lac operon IlvY is a LysR regulator, and it helps control transcription of a neighboring gene, ilvC. IlvY can eitherbend the DNA and block RNAP's access to ilvC's -35 promoter site, or it can allow access to the ilvC -35site, thereby promoting ilvC transcription. What determines whether llvY is repressing or activatingtranscription from the ilvC promoter?The presence of the co-inducer acetolactate - acetolactate binds to IlvY and changes IlvY's shape such that itdoesn't block the -35 of the ilvC promoter.IlvY represses ilvC transcription when the IlvC protein is bound to llvY, and it activates ilvC transcription whenthe llvC protein is not present to bind to llvY.The presence of the co-inducer valine - when valine is present, it binds llvY and causes llvY to represstranscription from the ilvC promoter.The presence of the co-inducer acetolactate - acetolactate induces negative supercoiling at the ilvC promoter,which represses ilvC transcription.

Answered: SigmaS is the stationary phase sigma…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

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I need help with both questions, please!

Sigmas is the stationary phase sigma factor. Which of the following is a likely site for RNAP-Sigmas
holoenzyme binding?
The terminator region of genes involved in starvation stress response
The -10 and -35 promoter regions of ribosomal RNA genes
The -10 and -35 promoter regions of genes involved in acid stress response
The Shine-Delgarno sequence of genes involved in oxidative stress response
The CAP operator of the lac operon

IlvY is a LysR regulator, and it helps control transcription of a neighboring gene, ilvC. IlvY can either
bend the DNA and block RNAP's access to ilvC's -35 promoter site, or it can allow access to the ilvC -35
site, thereby promoting ilvC transcription. What determines whether llvY is repressing or activating
transcription from the ilvC promoter?
The presence of the co-inducer acetolactate - acetolactate binds to IlvY and changes IlvY's shape such that it
doesn't block the -35 of the ilvC promoter.
IlvY represses ilvC transcription when the IlvC protein is bound to llvY, and it activates ilvC transcription when
the llvC protein is not present to bind to llvY.
The presence of the co-inducer valine - when valine is present, it binds llvY and causes llvY to repress
transcription from the ilvC promoter.
The presence of the co-inducer acetolactate - acetolactate induces negative supercoiling at the ilvC promoter,
which represses ilvC transcription.

Expert Solution

Step 1

Sigma factor-

A sigma factor is a protein needed for initiation of transcription in bacteria . it is a bacteria transcripition initiation factor that enables specific binding of RNA polymerase to gene promoters.

the sigma factor ,together with RNA polymerase is known as the RNA polymerase holoenzyme.

the number of sigma factor varies between bacterial species . E.coli has seven sigma factor .

sigma factor are distinguish by their characteristic molecular weight of 70 kDa.

the sigma factor in the RNA polymerase holoenzyme complex is required for the initiation of transcription.it is dissociated from the complex and the RNA continues elongation on its own

Different sigma factor are utilized under different environment conditions .these specialized sigma factor bind the promoters of genes appropriate to the environmental conditions increasing the transcription of those genes.