There are two genetic disorders that result from mutation in imprinted genes: Prader-Willi syndrome, Angelman syndrome. Angelman syndrome results from deletion of UBE3A, which is a gene imprinted such that only the maternal copy is expressed.In the pedigree above, individual I-1 is heterozygous for a deletion of UBE3A and does not have Angelman syndrome. Individual I-2 is homozygous wild type for UBE3A. Which individuals in the pedigree are at risk for exhibiting Angelman syndrome, if any? (Who could potentially have the syndrome, based on what alleles it is possible for them to inherit and express?) Question 8 options: Only I-1 could have been at risk. If he does not have the syndrome, no one in the pedigree could. Only III-1 is at risk I-1, II-2, and III-1 are all at risk Only II-2 is at risk No one in the pedigree is at risk Both II-2 and III-1 are at risk III-1 is only at risk if II-1 is heterozygous for the deletion, too This diagram is a pedigree chart used in genetics to track the inheritance of traits through generations. It uses standardized symbols: squares denote males, circles denote females, and lines represent familial relationships.### Explanation of the Pedigree Chart:**Generations:**- **I:** The first (topmost) generation includes one male (square) and one female (circle) connected by a horizontal line, indicating they are a couple.- **II:** The second generation has a couple similar to the first generation and a line downward from the couple connects to a vertical line leading to the next generation, as well as a lateral line leading to another sibling.- **III:** The third generation has one male (square) who is a child of the second generation couple.**Individuals:**- In each generation, individuals are labeled with Roman numerals indicating the generation and an Arabic number indicating their individual number within that generation. For example, "I-1" refers to the male in the first generation, and "II-2" refers to the female in the second generation.**Connections:**- Horizontal lines between a square and a circle represent mating.- Vertical lines represent the descendants of the mating pair, showing a direct line of descent through generations. This chart is a simple representation showing only direct lineage and can be used to study genetic traits or diseases passed down in a family.

Name: There are two genetic disorders that result from mutation in imprinted
Uploaded: 2024-03-20T06:42:55.000Z
Channel: Bartleby
Description: There are two genetic disorders that result from mutation in imprinted genes: Prader-Willi syndrome, Angelman syndrome. Angelman syndrome results from deletion of UBE3A, which is a gene imprinted such that only the maternal copy is expressed.In the

Rare hereditary disease called Angelman syndrome mostly impacts the nervous system, leading to…

Answered: There are two genetic disorders that…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

See similar textbooks

Related questions

Concept explainers

Topic Video

Question

There are two genetic disorders that result from mutation in imprinted genes: Prader-Willi syndrome, Angelman syndrome. Angelman syndrome results from deletion of UBE3A, which is a gene imprinted such that only the maternal copy is expressed.

In the pedigree above, individual I-1 is heterozygous for a deletion of UBE3A and does not have Angelman syndrome. Individual I-2 is homozygous wild type for UBE3A. Which individuals in the pedigree are at risk for exhibiting Angelman syndrome, if any? (Who could potentially have the syndrome, based on what alleles it is possible for them to inherit and express?)

Question 8 options:

	Only I-1 could have been at risk. If he does not have the syndrome, no one in the pedigree could.
	Only III-1 is at risk
	I-1, II-2, and III-1 are all at risk
	Only II-2 is at risk
	No one in the pedigree is at risk
	Both II-2 and III-1 are at risk
	III-1 is only at risk if II-1 is heterozygous for the deletion, too

This diagram is a pedigree chart used in genetics to track the inheritance of traits through generations. It uses standardized symbols: squares denote males, circles denote females, and lines represent familial relationships.

### Explanation of the Pedigree Chart:

**Generations:**
- **I:** The first (topmost) generation includes one male (square) and one female (circle) connected by a horizontal line, indicating they are a couple.
- **II:** The second generation has a couple similar to the first generation and a line downward from the couple connects to a vertical line leading to the next generation, as well as a lateral line leading to another sibling.
- **III:** The third generation has one male (square) who is a child of the second generation couple.

**Individuals:**
- In each generation, individuals are labeled with Roman numerals indicating the generation and an Arabic number indicating their individual number within that generation. For example, "I-1" refers to the male in the first generation, and "II-2" refers to the female in the second generation.

**Connections:**
- Horizontal lines between a square and a circle represent mating.
- Vertical lines represent the descendants of the mating pair, showing a direct line of descent through generations.

This chart is a simple representation showing only direct lineage and can be used to study genetic traits or diseases passed down in a family.

Expert Solution

Step by step

Solved in 7 steps

SEE SOLUTION Check out a sample Q&A here

Knowledge Booster

Learn more about

Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.

Similar questions