7006005004003002001003010MW|||E1 E2 E3 E4 E5 E6What type oftrinucleotide repeatdisease is Adamssyndrome most likely tobe?If implanted, whichembryo is most likely toproduce a blind baby?1. autosomal dominant3.2. X-linked dominantMW= molecularweight markers inbasepairsdotted lines indicatethe different lanes ofthe gelY-linked dominant4. autosomal recessive6. E15. X-linked recessive7. E2Which embryo ishomozygous for the wild- 8. E3type adams gene and9. E4should be used forimplantation?What is the mode ofinheritance for Adamssyndrome?10. E513.11. E612. A polyQ trinucleotide repeatdiseaseA non-polyQ trinucleotide repeatdisease Shown below is a pedigree for a completely penetrant trait called Adamssyndrome in which babies are born blind. This trait occurs when an allele ofthe adams gene is associated with ≥200 tandem trinucleotide repeats (thenormal number is 10). First cousins, III-1 and III-2 married and their first child(IV-1) was blind. For their next child, they decided to do in vitro fertilization withIII-1's sperm and III-2's eggs to generate six embryos (labeled E1-6). Wheneach embryo contained eight cells, a single cell was removed and genomicDNA was isolated. PCR reactions using primers that flank the trinucleotiderepeat region were then performed and the resulting fragments werefractionated on an agarose gel. PCR reactions using genomic DNA from III-1,III-2 and IV-1 were included as controls. The DNA was visualized using afluorescent dye and the gel is shown below.Based on this information, select the best answer from the list to the questionsbelow.||E1 = embryo 1IVE1E2 E3 E4 E5E6Agarose gel of PCR fragments generated using genomic DNA andprimers flanking the trinucleotide repeat region

Name: 7006005004003002001003010MW|||E1 E2 E3 E4 E5 E6What type oftrinucleot
Uploaded: 2024-03-20T06:42:55.000Z
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Description: 7006005004003002001003010MW|||E1 E2 E3 E4 E5 E6What type oftrinucleotide repeatdisease is Adamssyndrome most likely tobe?If implanted, whichembryo is most likely toproduce a blind baby?1. autosomal dominant3.2. X-linked dominantMW= molecularweight m