The terminal complement proteins polymerize to form pores in membranes that can kill certain pathogens. The terminal components of the complement pathway assemble to form a membrane attack complex that can induce pathogen lysis and death. Yet, evidence indicates that this feature of complement is less important than the earlier steps that promote pathogen opsonization and induce inflammation. This conclusion is based on:In vitro experiments showing that very few species of bacteria are susceptible to lysis by the membrane attack complexExperiments indicating that only bacteria, but not viruses or fungi, are susceptible to lysis by the membrane attack complexThe very low levels of terminal complement components in the serumThe fact that other mammalian species lack the terminal components of the complement pathway needed to form the membrane attack complexThe limited susceptibility to infections of patients with deficiencies in terminal complement components

The correct answer is 5. The limited susceptibility to infections of patients with deficiencies in…

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Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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The terminal complement proteins polymerize to form pores in membranes that can kill certain pathogens. The terminal components of the complement pathway assemble to form a membrane attack complex that can induce pathogen lysis and death. Yet, evidence indicates that this feature of complement is less important than the earlier steps that promote pathogen opsonization and induce inflammation. This conclusion is based on:

In vitro experiments showing that very few species of bacteria are susceptible to lysis by the membrane attack complex
Experiments indicating that only bacteria, but not viruses or fungi, are susceptible to lysis by the membrane attack complex
The very low levels of terminal complement components in the serum
The fact that other mammalian species lack the terminal components of the complement pathway needed to form the membrane attack complex
The limited susceptibility to infections of patients with deficiencies in terminal complement components

Definition Definition Chemical process in which one or more monomers combine to produce a very large chain-like molecule called a polymer. The functional groups present on the monomers and their steric effects are responsible for polymerization through a sequence of reactions that vary in complexity. There exists a stable covalent chemical bond between monomers that sets apart polymerization from other processes.

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