The pyruvate dehydrogenase complex catalyzes the oxidative decarboxylation of pyruvate to form acetyl‑CoA. E1E1 , E2E2 , and E3E3 are abbreviations for the enzymes of the complex. Classify the enzyme names, prosthetic groups, and reactions as E1E1 , E2E2 , or E3E3 .

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Chapter1: Biochemistry: An Evolving Science
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The pyruvate dehydrogenase complex catalyzes the oxidative decarboxylation of pyruvate to form acetyl‑CoA. E1E1 , E2E2 , and E3E3 are abbreviations for the enzymes of the complex. Classify the enzyme names, prosthetic groups, and reactions as E1E1 , E2E2 , or E3E3 .

E1
E2
E3
pyruvate dehydrogenase
dihydrolipoyl transacetylase
dihydrolipoyl
(dihydrolipoamide acetyltransferase)
(dihydrolipoamide) dehydrogenase
thiamine pyrophosphate (also called TPP or
TDP)
lipoamide (or lipoate)
FAD
hydroxyethyl group transferred to lipoamide
transfer of acetyl group to coenzyme A
decarboxylation of pyruvate
dihydrolipoamide is oxidized to lipoamide
Transcribed Image Text:E1 E2 E3 pyruvate dehydrogenase dihydrolipoyl transacetylase dihydrolipoyl (dihydrolipoamide acetyltransferase) (dihydrolipoamide) dehydrogenase thiamine pyrophosphate (also called TPP or TDP) lipoamide (or lipoate) FAD hydroxyethyl group transferred to lipoamide transfer of acetyl group to coenzyme A decarboxylation of pyruvate dihydrolipoamide is oxidized to lipoamide
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