Compare and contrast Pyruvate Dehydrogenase with a-ketoglutarate dehydrogenase Outline the mechanisms of both enzymes. Discuss the functions of the coenzymes. List the similarities and the differences between the 2 enzymes. Both are very large membrane bound complexes. What are the advantages of this strategy? How detailed is the enzyme structure known below(It's  Pyruvate Dehydrogenase )? What insight(s) does this structural detail give you about the enzyme mechanism.

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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Compare and contrast Pyruvate Dehydrogenase with a-ketoglutarate dehydrogenase
Outline the mechanisms of both enzymes. Discuss the functions of the coenzymes. List the similarities and the
differences between the 2 enzymes. Both are very large membrane bound complexes. What are the advantages
of this strategy?
How detailed is the enzyme structure known below(It's  Pyruvate Dehydrogenase )? What insight(s) does this structural detail give you about the enzyme mechanism.

a
N
f
E3
NADH + H+
E2p
H3C S-COA
1-78
LD1
E1p
HS HS
FAD
NAD+
FADH₂
CoA-SH
LD
PSBD
105-180
LD2
LD
Catalytic
core
E3
b
-SH
TPP
носно
xx
TPP
d
pyruvate + CoA + NAD*
TPP
Lipoate
FAD
206-281
LD3
CH3
acetyl-CoA + CO₂
+ NADH + H*
مسلم
dihydrolipoyl
moiety
326-
371
PSBD
E1p
LD
CO₂
CH3
E1p
-14 Å
PSBD
COO
lysine 245
(E2p LD3)
395-629
Catalytic core
Catalytic
core
E3
C
C
E1p
PSBD
LD
Catalytic
core
E3
E1p/E3
E2p
E1p
PSBD
Catalytic
core
LD
E3
Transcribed Image Text:a N f E3 NADH + H+ E2p H3C S-COA 1-78 LD1 E1p HS HS FAD NAD+ FADH₂ CoA-SH LD PSBD 105-180 LD2 LD Catalytic core E3 b -SH TPP носно xx TPP d pyruvate + CoA + NAD* TPP Lipoate FAD 206-281 LD3 CH3 acetyl-CoA + CO₂ + NADH + H* مسلم dihydrolipoyl moiety 326- 371 PSBD E1p LD CO₂ CH3 E1p -14 Å PSBD COO lysine 245 (E2p LD3) 395-629 Catalytic core Catalytic core E3 C C E1p PSBD LD Catalytic core E3 E1p/E3 E2p E1p PSBD Catalytic core LD E3
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Enzymes are essential for the functioning of living cells and play a crucial role in maintaining health and preventing disease. Any changes in the normal functioning of enzymes can result in cellular dysfunction and disease. Understanding enzymes and how they work is a key area of study in biochemistry and is important for developing treatments for a variety of diseases

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