Remembering that the Pyruvate dehydrogenase complex and the alpha ketoglugarate complex catalyze similar reactions, please match the following terms with its description:Dihydrolipoyl dehydrogenase (E3)1) an alpha-keto acid that undergoes oxidative decarboxylation2) is analogous to the pyruvate dehydrogenase reaction in which there's an oxidative decarboxylation with a concomitant formation of an acyl-CoA thioester3) is analogous to the pyruvate dehydrogenase reaction and the isocitrate dehydrogenase reaction in which there's an oxidative decarboxylation with a concomitant formation of an acyl-CoAthioester4) catalyzes the oxidative decarboxylation of alpha ketoglutarate5) regenerates active dihydrolipoyl transacetylase (E2)6) catalyzes the oxidative decarboxylation of succinyl coa7) catalyzes the oxidative decarboxylation of alpha isocitrate8) catalyzes the formation of Succinyl CoAAlpha ketoglutarateThe alpha ketoglutarate dehydrogenasecomplexAlpha ketoglutarate dehydrogenase (E1)Dihydrolipoyl transacetylase (E2)

Pyruvate is the end product of glycolysis. Under aerobic conditions, pyruvate is oxidised into…

Answered: Remembering that the Pyruvate…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Considering that triacylglycerols get hydrolyzed in the small intestine because of pancreatic lipases, write the reactions using structural formulas by which a 7-carbon fatty acid is activated and oxidized in the liver of this patient. Indicate cofactors and underscore the final CoA products.
The oxidation of Gly-3-P to 1,3-bisphosphoglycerate proceeds with an unfavorable AG which equals 6.3 KJ/mol, yet the flow through this point in the glycolytic pathway proceeds smoothly. Why???
3. (а) (coenzyme A), NAD+ (oxidized nicotinamide adenine dinucleotide), FAD (oxidized flavin adenine dinu- cleotide), and a five-membered ring for oxidized lipoamide, and using structural formulas outline the reactions for the oxidative decarboxylation of a-ketoglutarate catalyzed by the aKG dehydrogenase complex. Name the 3 enzymes catalyzing the reactions underlying the conversion of a-ketoglutarate. Using the following abbreviations for cofactors: TPP (thiamine pyrophosphate), COASH
In 1937, two German biochemists published a paper proposing these reactions as part of glucose oxidation: citrate → isocitrate → α-ketoglutarate →succinate → fumarate → malate → oxaloacetate. Adding succinate, fumarate, or malate to thin slices of tissue increased oxygen consumption, supporting the hypothesis that these molecules are intermediates in the process. However, they were puzzled by the observation that these intermediates were still present in the reaction mixture at the end of the experiment. They had thought that intermediates would be consumed as they were converted to the next molecule in the pathway. What explains the observation that these intermediates were still present? a) The pathway is a cycle, constantly regenerating intermediates as glucose is broken down. b) Succinate, fumarate, and malate are not reactants but catalysts, and catalysts are not consumed in the process. c) Succinate, fumarate, and malate increase metabolism and therefore oxygen consumption,…
What four allosteric enzymes or enzyme complexes are responsible for the regulation of the citric acid cycle? Select all that apply. Malate dehydrogenase Fumarase Succinyl CoA synthetase Aconitase a-ketogluatarate dehydrogenase Succinate dehydrogenase Pyruvate dehydrogenase Citrate synthase Isocitrate dehydrogenase
What is the fate of the radioactive label when each of the following compounds is added to a cell extract containing the enzymes and cofactors of the citric acid cycle and the pyruvate dehydrogenase complex? P.S. A detailed steps explaination would be greatly appreciated. Also, any tips on how to solve such problems if possible? Is there any particular fate that C atoms of the R group for example, have, at the end of the cycle? I usually think of drawing out each step and solving but I believe that there must be a shorter, smarter way to do it and similar questions. Thank you!
Suppose a liver extract capable of carrying out normal metabolic reactions (including gluconeogenesis) is incubated with pyruvate partially labeled with deuterium at the methyl group (see below: D= deuterium, i.e., H-2) a) Explain why the oxaloacetate formed in step 1 of gluconeogenesis is only partially labeled (i.e., some of the oxaloacetate is labeled and some is not). b) Where would the label be found in glucose?

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