Acetyl-CoA + HCO3- → Malonyl-CoA However, the ΔG of this reaction is much greater than zero. In other words, it is endergonic. Which of the following reactions is most likely to be coupled to the carboxylation of acetyl-CoA so that it can occur? the isomerization of glucose 6-phosphate into fructose 6-phosphate - a readily reversible reaction with a negative ΔG the dehydration of 2-phosphoglycerate into phosphoenolpyruvate - a readily reversible reaction with a positive ΔG the hydrolysis of ATP into ADP and Pi - an essentially irreversible reaction with a negative ΔG the reduction of NAD+ into NADH - an essentially irreversible reaction with a positive ΔG

Biochemistry
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Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
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Chapter1: Biochemistry: An Evolving Science
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Acetyl-CoA + HCO3- → Malonyl-CoA

However, the ΔG of this reaction is much greater than zero. In other words, it is endergonic. Which of the following reactions is most likely to be coupled to the carboxylation of acetyl-CoA so that it can occur?

  1. the isomerization of glucose 6-phosphate into fructose 6-phosphate - a readily reversible reaction with a negative ΔG
  2. the dehydration of 2-phosphoglycerate into phosphoenolpyruvate - a readily reversible reaction with a positive ΔG
  3. the hydrolysis of ATP into ADP and Pi - an essentially irreversible reaction with a negative ΔG
  4. the reduction of NAD+ into NADH - an essentially irreversible reaction with a positive ΔG
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