Fatty acids are activated for breakdown through the action of acyl-CoA synthestase. Which of the followingstatements regarding acyl-CoA synthetase is not true?● It catalyzes the addition of CoA to the fatty acidOne of the products of the reaction is ADP.O The free energy change for the reaction catalyzed by this reaction is close to 0 kJ/mol, but the subsequent hydrolysis ofpyrophosphate drives the reaction forward.O The reaction results in the formation of a thioester bond.

Fatty acids are oxidised in the mitochondria. The fatty acid cannot enter the mitochondria but fatty…

Answered: Fatty acids are activated for breakdown…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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If a liver extract capable of carrying out normal metabolic reactions (including gluconeogenesis) is incubated with labeled pyruvate labeled with oxygen-18 at the carboxylate oxygen atom shown, where would the label be found in glucose? Explain both in words and illustration. If any of the positions be partially labeled, indicate that clearly and explain.
Synthesis of the activated form of acetate (acetyl-CoA) is carried out in an ATP-dependent process:(a) The ΔG′° for hydrolysis of acetyl-CoA to acetate and CoA is −32.2 kJ/mol and that for hydrolysis of ATP to AMP and PPi is −30.5 kJ/mol. Calculate ΔG′° for the ATPdependent synthesis of acetyl-CoA.(b) Almost all cells contain the enzyme inorganic pyrophosphatase, which catalyzes the hydrolysis of PPi to Pi. What effect does the presence of this enzyme have on the synthesis of acetyl-CoA? Explain.
[AktivGrid] Draw the product of the reaction of isocitrate catalyzed by isocitrate dehydrogenase in the TCA (citric acid) cycle. Provide the structure in the protonation state found in physiological conditions. 9 H-C-OH 800- -H CH₂ ° Coo of NAD+ dehydrogen isocitrate ase NADH, H*, Drawing CO2
9. The equation below depicts the first step of the citric acid cycle. H0 CoA-SH CH-C + 0=C-CO0 HO C-COO citrate s-COA ČH2-COO synthase ČH2 -CO0 Citrate Acetyl-CoA Oxaloacetate AG" = -32.2 kJ/mol a) Explain the chemical conversions that take place during this step. b) Why is this reaction energetically favorable? Explain.
The following reaction, the last reaction in beta-oxidation, is an example of a: Enzyme Enzyme-H S-CoA S-COA H2C H3C CoA s–CoA C H2 CH2 R S-COA S-COA S-COA O A. Nucleophilic acyl substitution O B. Electrophilic addition OC. Nucleophilic addition D. Aldol condensation O E. Hydrohalogenation
, which indicates AG for each glycolytic reac- tion under intracellular conditions. Assume that glyceraldehyde-3- phosphate dehydrogenase was inhibited with iodoacetic acid. Which glycolytic intermediate would you expect to accumulate most rapidly, and why?
Mitochondria were isolated from a rat heart. Figure 4 shows the relationship between palmitoyl carnithine I activity (determined by [H] palmitoyl carnithine production) and the concentration of malonyl CoA. Using this result explain the effect of malonyl CoA on fatty acid breakdown. 10 10 15 2.0 2.5 Malonyl CoA (uM) Figure 4 ['H]palmitoyl carnitine production (nmol/min/mg protein)
L What is the difference between the type of oxidation catalyzed by acyl-CoA dehydrogenase and that catalyzed by b-hydroxyCoA dehydrogenase
Provide a reasonable step-wise mechanism for the reaction below, involving TPP as acoenzyme (can abbreviate the pyrophosphate as R), and invoking any general acids or base fromacetolactate synthase that you might need .
Arrange the steps of breakdown of oleic acid (pictured below) in the correct order. 1 2 3 4 5 activation by acyl-CoAsynthe ✓ [Choose ] one cycle ofß-oxidationbeginning at the enoyl-CoAhydratasestep three cycles ofẞ-oxidation five cycles ofß-oxidation activation by acyl-CoAsynthetase enoyl-CoAisomeraseactivity enoyl-CoAisomeraseactivity V one cycle ofß-oxidationbegini V five cycles ofß-oxidation OH
Given the following statements, identify which are true and which are not. (1) Two ribose subunits are present in the coenzyme flavin adenine dinucleotide. (2) In the common metabolic pathway, 10 molecules of ATP are produced per acetyl CoA catabolized. (3) The purpose of step 2 in the CAC is to convert a secondary alcohol to a tertiary alcohol.
When the identical subunits of chicken liver fatty acid synthase are dissociated in vitro, all of the activities can be detected in the separated subunits except for the β-ketoacyl synthase reaction and the overall synthesis of palmitate. Explain these observations.

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