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Before a fatty acid can undergo B-oxidation it must be:

Before a fatty acid can undergo B-oxidation it must be:

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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**Question:** Before a fatty acid can undergo β-oxidation it must be: - O Transport of the FA into the mito. matrix - O Hydrolysis of the carboxyl group from the FA - O Carboxylation of Acetyl-CoA to form malonyl-CoA - O Activation of the FA with Coenzyme A - O Oxidation of the FA yielding a Δ2-enoyl intermediate **Explanation:** This question is asking about the preparatory step necessary for a fatty acid (FA) to undergo β-oxidation, a metabolic process that breaks down fatty acids to generate acetyl-CoA, which then enters the citric acid cycle. Each option provides a potential step that might occur before β-oxidation commences. Correct answer involves understanding that fatty acids must first be activated by Coenzyme A, forming fatty acyl-CoA in a reaction catalyzed by acyl-CoA synthetase. Once activated, the fatty acyl-CoA can be transported into the mitochondrial matrix, where β-oxidation occurs.
Transcribed Image Text:**Question:** Before a fatty acid can undergo β-oxidation it must be: - O Transport of the FA into the mito. matrix - O Hydrolysis of the carboxyl group from the FA - O Carboxylation of Acetyl-CoA to form malonyl-CoA - O Activation of the FA with Coenzyme A - O Oxidation of the FA yielding a Δ2-enoyl intermediate **Explanation:** This question is asking about the preparatory step necessary for a fatty acid (FA) to undergo β-oxidation, a metabolic process that breaks down fatty acids to generate acetyl-CoA, which then enters the citric acid cycle. Each option provides a potential step that might occur before β-oxidation commences. Correct answer involves understanding that fatty acids must first be activated by Coenzyme A, forming fatty acyl-CoA in a reaction catalyzed by acyl-CoA synthetase. Once activated, the fatty acyl-CoA can be transported into the mitochondrial matrix, where β-oxidation occurs.
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