HCO3 + Glutamine + ATP Carbamoyl phosphate + Aspartate AT Case N-carbamoylaspartate -UMP UTP CTP
HCO3 + Glutamine + ATP Carbamoyl phosphate + Aspartate AT Case N-carbamoylaspartate -UMP UTP CTP
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Transcribed Image Text:HCO3 + Glutamine + ATP
Carbamoyl phosphate + Aspartate
AT Case
Figure 1: Pyrimidine synthetic pathway.
N-carbamoylaspartate
UMP
UTP
CTP

Transcribed Image Text:Back in 1962, Gerhart and Pardee developed a model for the regulation of the activity of the ATCase
enzyme by CTP and ATP, using the pathway given in Figure 1. Describe that model, using
information presented here as well as what you have learned about allosteric enzymes. Be sure to
include a sentence explaining the physiological significance of your model.
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