The diagram describes a signaling pathway involved Protein Kinase A (PKA). Activated PKAphosphorylates a gene regulatory protein called CREB that then activates transcription of sometarget genes.adrenalineactivated GPCR[Select]activated,a subunit ofG protein (G)CYTOSOLNUCLEUS[ Select]active PKAphosphorylated by PKA[Select]hydrolyze GTPGTPactivatedadenylyl cyclaseinactive PKADNAATPactivated, phosphorylatedgene regulatory proteinRNAcyclic AMP| Select]PKA from binding to its nuclear import receptorWhich situation (s) described below would lead to an increase in the transcription of these targetgenes? Mark yes or no for each of the following choices.activePKACnuclear poreactivated target geneTRANSCRIPTIONa mutation in the CREB gene that produces a protein that cannot bea mutation in the nuclear import sequence of PKA that preventsthe enzyme unable to interact with the a subunit of the G protein✓a mutation in the a unit of the G-protein that makes G, unable toVa mutation in the gene that encodes adenylyl cyclase that renders

Answered: The diagram describes a signaling…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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The diagram describes a signaling pathway involved Protein Kinase A (PKA). Activated PKA
phosphorylates a gene regulatory protein called CREB that then activates transcription of some
target genes.
adrenaline
activated GPCR
[Select]
activated,
a subunit of
G protein (G)
CYTOSOL
NUCLEUS
[ Select]
active PKA
phosphorylated by PKA
[Select]
hydrolyze GTP
GTP
activated
adenylyl cyclase
inactive PKA
DNA
ATP
activated, phosphorylated
gene regulatory protein
RNA
cyclic AMP
| Select]
PKA from binding to its nuclear import receptor
Which situation (s) described below would lead to an increase in the transcription of these target
genes? Mark yes or no for each of the following choices.
active
PKA
C
nuclear pore
activated target gene
TRANSCRIPTION
a mutation in the CREB gene that produces a protein that cannot be
a mutation in the nuclear import sequence of PKA that prevents
the enzyme unable to interact with the a subunit of the G protein
✓a mutation in the a unit of the G-protein that makes G, unable to
V
a mutation in the gene that encodes adenylyl cyclase that renders

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Step 1

Protein Kinase A:

The family of enzymes known as protein kinase A (PKA) in cell biology depends on cellular levels of cyclic AMP for its action (cAMP). PKA is a protein kinase that is cAMP-dependent. PKA performs a variety of tasks in the cell, including controlling the metabolism of sugar, lipids, and glycogen. Contrary to 5'-AMP-activated protein kinase, it shouldn't be mistaken with it (AMP-activated protein kinase).

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