You have discovered two new inhibitors that inhibit enzymes involved in the apoptotic pathway shown below. Both inhibitors are newly identified proteins. You know that one of these proteins is a noncompetitive inhibitor of the kinase, Akt. Another protein is a competitive inhibitor of the phosphatase (i.e. a regulatory enzyme) that removes phosphates from Akt. survival signal inactive Bad active Akt Bad PHOSPHORYLATION OF Bad RELEASES ACTIVE Bcl2 PROMOTION OF CELL SURVIVAL BY INHIBITION OF APOPTOSIS inactive Bcl2 active Bcl2 Describe how each inhibitor would affect the apoptotic pathway shown above. Be specific about how the normal cascade works and how the inhibitor would change the signaling cascade or final outcome of the pathway. Which inhibitor will cause an artificial amplification of the cascade shown above and why? Which of the inhibitors would you prescribe to a cancer patient and why?
You have discovered two new inhibitors that inhibit enzymes involved in the apoptotic pathway shown below. Both inhibitors are newly identified proteins. You know that one of these proteins is a noncompetitive inhibitor of the kinase, Akt. Another protein is a competitive inhibitor of the phosphatase (i.e. a regulatory enzyme) that removes phosphates from Akt. survival signal inactive Bad active Akt Bad PHOSPHORYLATION OF Bad RELEASES ACTIVE Bcl2 PROMOTION OF CELL SURVIVAL BY INHIBITION OF APOPTOSIS inactive Bcl2 active Bcl2 Describe how each inhibitor would affect the apoptotic pathway shown above. Be specific about how the normal cascade works and how the inhibitor would change the signaling cascade or final outcome of the pathway. Which inhibitor will cause an artificial amplification of the cascade shown above and why? Which of the inhibitors would you prescribe to a cancer patient and why?
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Proteins
We generally tend to think of proteins only from a dietary lens, as a component of what we eat. However, they are among the most important and abundant organic macromolecules in the human body, with diverse structures and functions. Every cell contains thousands and thousands of proteins, each with specific functions. Some help in the formation of cellular membrane or walls, some help the cell to move, others act as messages or signals and flow seamlessly from one cell to another, carrying information.
Protein Expression
The method by which living organisms synthesize proteins and further modify and regulate them is called protein expression. Protein expression plays a significant role in several types of research and is highly utilized in molecular biology, biochemistry, and protein research laboratories.
Question
Transcribed Image Text:You have discovered two new inhibitors that inhibit enzymes involved in the apoptotic pathway shown below. Both inhibitors are newly identified
proteins. You know that one of these proteins is a noncompetitive inhibitor of the kinase, Akt. Another protein is a competitive inhibitor of the
phosphatase (i.e. a regulatory enzyme) that removes phosphates from Akt.
survival signal
inactive Bad
active Akt
Bad
PHOSPHORYLATION OF Bad
PROMOTION OF CELL
RELEASES ACTIVE Bcl2
SURVIVAL BY INHIBITION
inactive Bcl2
OF APOPTOSIS
active Bcl2
Describe how each inhibitor would affect the apoptotic pathway shown above. Be specific about how the normal cascade works and how the
inhibitor would change the signaling cascade or final outcome of the pathway.
Which inhibitor will cause an artificial amplification of the cascade shown above and why?
Which of the inhibitors would you prescribe to a cancer patient and why?
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