When a signal binds to the Tyrosine kinase receptor (RTK), you have studied that a list of events occur sequentially. Map the events in the correct order from 1st to the last step.
When a signal binds to the Tyrosine kinase receptor (RTK), you have studied that a list of events occur sequentially. Map the events in the correct order from 1st to the last step.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Question
When a signal binds to the Tyrosine kinase receptor (RTK), you have studied that a list of events occur sequentially. Map the events in the correct order from 1st to the last step.
![Gene targets
DNA
Cell proliferation, survival,
migration, and differentiation
CYTOPLASM
NUCLEUS
Drag and drop options on the right-hand side and submit. For keyboard navigation. SHOW MORE V
leads to the formation of cross-linked dimers
= 2
(dimerization)
phosphorylated cytoplasmic tails of RTKS serve as
docking platforms for various intracellular proteins
= 4
involved in signal transduction
neighboring RTKS to associate with each other
= 5
each RTK in the dimer phosphorylates multiple
= 3
tyrosines on the other RTK
activation of the tyrosine kinase activity in these RTKS
= 1
through phosphorylation](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F3e972176-eae1-4b74-9b20-fcbad417c77d%2Fa8b137ea-a383-4e7a-8235-bbfd5828af67%2F70eudtf_processed.png&w=3840&q=75)
Transcribed Image Text:Gene targets
DNA
Cell proliferation, survival,
migration, and differentiation
CYTOPLASM
NUCLEUS
Drag and drop options on the right-hand side and submit. For keyboard navigation. SHOW MORE V
leads to the formation of cross-linked dimers
= 2
(dimerization)
phosphorylated cytoplasmic tails of RTKS serve as
docking platforms for various intracellular proteins
= 4
involved in signal transduction
neighboring RTKS to associate with each other
= 5
each RTK in the dimer phosphorylates multiple
= 3
tyrosines on the other RTK
activation of the tyrosine kinase activity in these RTKS
= 1
through phosphorylation
![When a signal binds to the Tyrosine kinase receptor (RTK), you have studied that a list of events occur sequentially. Map the events
in the correct order from 1st to the last step.
RTK
Tyrosine kinase
domain
Phosphorylated tyrosines
PLASMA MEMBRANE
MAP kinase
signaling
JAK/STAT
signaling
PI3K/AKTI
signaling
Gene targets
DNA
Cell proliferation, survival,
migration, and differentiation
CYTOPLASM
NUCLEUS
Drag and drop options on the right-hand side and submit. For keyboard navigation. SHOW MORE V
leads to the formation of cross-linked dimers
2
(dimerization)
II
000
000](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F3e972176-eae1-4b74-9b20-fcbad417c77d%2Fa8b137ea-a383-4e7a-8235-bbfd5828af67%2Fc9wwpph_processed.png&w=3840&q=75)
Transcribed Image Text:When a signal binds to the Tyrosine kinase receptor (RTK), you have studied that a list of events occur sequentially. Map the events
in the correct order from 1st to the last step.
RTK
Tyrosine kinase
domain
Phosphorylated tyrosines
PLASMA MEMBRANE
MAP kinase
signaling
JAK/STAT
signaling
PI3K/AKTI
signaling
Gene targets
DNA
Cell proliferation, survival,
migration, and differentiation
CYTOPLASM
NUCLEUS
Drag and drop options on the right-hand side and submit. For keyboard navigation. SHOW MORE V
leads to the formation of cross-linked dimers
2
(dimerization)
II
000
000
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