You have discovered a novel receptor that contains a NLS, a KKXX, and a mitochondrial localization signal sequence. What would be the most likely destination of the protein if the NLS signal sequence was removed? The protein would be retained in the nucleus The protein would localize to the plasma membrane The protein would stay in the cytoplasm The protein would be retained in the ER The protein would localize to the mitochondria

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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**Question:**

You have discovered a novel receptor that contains an NLS, a KKXX, and a mitochondrial localization signal sequence. What would be the most likely destination of the protein if the NLS signal sequence was removed?

**Options:**

- ○ The protein would be retained in the nucleus
- ○ The protein would localize to the plasma membrane
- ○ The protein would stay in the cytoplasm
- ○ The protein would be retained in the ER
- ○ The protein would localize to the mitochondria

**Explanation:**

This question is about determining the likely destination of a protein when the nuclear localization signal (NLS) is removed. The options consider various possible cellular localizations, reflecting different signal sequences. 

The presence of KKXX and mitochondrial localization signal suggests potential localizations in either the ER or mitochondria, depending on dominant targeting signals when the NLS is absent.
Transcribed Image Text:**Question:** You have discovered a novel receptor that contains an NLS, a KKXX, and a mitochondrial localization signal sequence. What would be the most likely destination of the protein if the NLS signal sequence was removed? **Options:** - ○ The protein would be retained in the nucleus - ○ The protein would localize to the plasma membrane - ○ The protein would stay in the cytoplasm - ○ The protein would be retained in the ER - ○ The protein would localize to the mitochondria **Explanation:** This question is about determining the likely destination of a protein when the nuclear localization signal (NLS) is removed. The options consider various possible cellular localizations, reflecting different signal sequences. The presence of KKXX and mitochondrial localization signal suggests potential localizations in either the ER or mitochondria, depending on dominant targeting signals when the NLS is absent.
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