The diagram introduces the pathway through which nitric oxide (NO) triggers smooth muscle relaxation in a blood-vessel wall and leads to increase in blood flow. It also contains information on how the drug nitroglycerine functions to relieve angina. (A) smooth muscle cell lumen of blood vessel acetylcholine arginine- basal lamina endothelial cell NO endothelial cell Fig 15-40 M Blogy of the Cell 6 (Galand Science 2015 [ Select] activated NO synthase (NOS) [ Select] RAPID DIFFUSION OF NO ACROSS MEMBRANES [Select] that it cannot produce cGMP [Select] The drug nitroglycerine is directly converted to NO and triggers relaxation of the coronary blood vessels to relieve angina (chest pain or discomfort that occurs if an area of the heart muscle doesn't get enough oxygen-rich blood). usually a symptom of coronary heart disease NO bound to guanylyl cyclase Which of the following situations would lead to relaxation of the smooth muscle cells in the absence of acetylcholine? Mark yes or no for each of the following choices. A smooth muscle cell that has a mutation in guanylyl cyclase such GTP cycli GMP RAPID RELAXATION OF SMOOTH MUSCLE CELL smooth muscle cell Nitroglycerin treatment A drug that inhibits the enzyme that converts arginine to NO A drug that increases IP3 production independent of acetylcholine
The diagram introduces the pathway through which nitric oxide (NO) triggers smooth muscle relaxation in a blood-vessel wall and leads to increase in blood flow. It also contains information on how the drug nitroglycerine functions to relieve angina. (A) smooth muscle cell lumen of blood vessel acetylcholine arginine- basal lamina endothelial cell NO endothelial cell Fig 15-40 M Blogy of the Cell 6 (Galand Science 2015 [ Select] activated NO synthase (NOS) [ Select] RAPID DIFFUSION OF NO ACROSS MEMBRANES [Select] that it cannot produce cGMP [Select] The drug nitroglycerine is directly converted to NO and triggers relaxation of the coronary blood vessels to relieve angina (chest pain or discomfort that occurs if an area of the heart muscle doesn't get enough oxygen-rich blood). usually a symptom of coronary heart disease NO bound to guanylyl cyclase Which of the following situations would lead to relaxation of the smooth muscle cells in the absence of acetylcholine? Mark yes or no for each of the following choices. A smooth muscle cell that has a mutation in guanylyl cyclase such GTP cycli GMP RAPID RELAXATION OF SMOOTH MUSCLE CELL smooth muscle cell Nitroglycerin treatment A drug that inhibits the enzyme that converts arginine to NO A drug that increases IP3 production independent of acetylcholine
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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![The diagram introduces the pathway through which nitric oxide (NO) triggers smooth muscle
relaxation in a blood-vessel wall and leads to increase in blood flow. It also contains information
on how the drug nitroglycerine functions to relieve angina.
(A)
smooth muscle cell
(B)
lumen of
blood vessel
acetylcholine
arginine-
basal lamina
endothelial cell
NO
endothelial cell
Figure 15-40 Molecular Biology of the Cell 6 (Garland Science 2015)
[Select]
activated
NO synthase
(NOS)
[Select]
RAPID DIFFUSION OF NO
ACROSS MEMBRANES
[Select]
that it cannot produce cGMP
[Select]
The drug nitroglycerine is directly converted to
NO and triggers relaxation of the coronary
blood vessels to relieve angina (chest pain or
discomfort that occurs if an area of the heart
muscle doesn't get enough oxygen-rich blood),
usually a symptom of coronary heart disease
NO bound to
guanylyl cyclase
GTP
Which of the following situations would lead to relaxation of the smooth muscle cells in the
absence of acetylcholine? Mark yes or no for each of the following choices.
A smooth muscle cell that has a mutation in guanylyl cyclase such
cyclic
GMP
RAPID RELAXATION
OF SMOOTH MUSCLE CELL
smooth muscle cell
Nitroglycerin treatment
A drug that inhibits the enzyme that converts arginine to NO
A drug that increases IP3 production independent of acetylcholine](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F952a9716-055c-40f9-a463-0115375dbdab%2Fc0c2709a-509d-4198-a88b-85b6baca9b9b%2Fj0yevc_processed.jpeg&w=3840&q=75)
Transcribed Image Text:The diagram introduces the pathway through which nitric oxide (NO) triggers smooth muscle
relaxation in a blood-vessel wall and leads to increase in blood flow. It also contains information
on how the drug nitroglycerine functions to relieve angina.
(A)
smooth muscle cell
(B)
lumen of
blood vessel
acetylcholine
arginine-
basal lamina
endothelial cell
NO
endothelial cell
Figure 15-40 Molecular Biology of the Cell 6 (Garland Science 2015)
[Select]
activated
NO synthase
(NOS)
[Select]
RAPID DIFFUSION OF NO
ACROSS MEMBRANES
[Select]
that it cannot produce cGMP
[Select]
The drug nitroglycerine is directly converted to
NO and triggers relaxation of the coronary
blood vessels to relieve angina (chest pain or
discomfort that occurs if an area of the heart
muscle doesn't get enough oxygen-rich blood),
usually a symptom of coronary heart disease
NO bound to
guanylyl cyclase
GTP
Which of the following situations would lead to relaxation of the smooth muscle cells in the
absence of acetylcholine? Mark yes or no for each of the following choices.
A smooth muscle cell that has a mutation in guanylyl cyclase such
cyclic
GMP
RAPID RELAXATION
OF SMOOTH MUSCLE CELL
smooth muscle cell
Nitroglycerin treatment
A drug that inhibits the enzyme that converts arginine to NO
A drug that increases IP3 production independent of acetylcholine
![The diagram describes a signaling pathway involved Protein Kinase A (PKA). Activated PKA
phosphorylates a gene regulatory protein called CREB that then activates transcription of some
target genes.
adrenaline
activated GPCR
activated
a subunit of
G protein (G₂)
CYTOSOL
[Select]
NUCLEUS
active PKA
[Select]
phosphorylated by PKA
GTP
[Select]
hydrolyze GTP
[Select]
activated
adenylyl cyclase
inactive PKA
DNA
ATP
activated, phosphorylated
gene regulatory protein
RNA
cyclic AMP
PKA from binding to its nuclear import receptor
active
PKA
Which situation (s) described below would lead to an increase in the transcription of these target
genes? Mark yes or no for each of the following choices.
C
nuclear pore
activated target gene
TRANSCRIPTION
a mutation in the CREB gene that produces a protein that cannot be
a mutation in the nuclear import sequence of PKA that prevents
the enzyme unable to interact with the a subunit of the G protein
a mutation in the a unit of the G-protein that makes Ga unable to
a mutation in the gene that encodes adenylyl cyclase that renders](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F952a9716-055c-40f9-a463-0115375dbdab%2Fc0c2709a-509d-4198-a88b-85b6baca9b9b%2Fkuua6p.jpeg&w=3840&q=75)
Transcribed Image Text:The diagram describes a signaling pathway involved Protein Kinase A (PKA). Activated PKA
phosphorylates a gene regulatory protein called CREB that then activates transcription of some
target genes.
adrenaline
activated GPCR
activated
a subunit of
G protein (G₂)
CYTOSOL
[Select]
NUCLEUS
active PKA
[Select]
phosphorylated by PKA
GTP
[Select]
hydrolyze GTP
[Select]
activated
adenylyl cyclase
inactive PKA
DNA
ATP
activated, phosphorylated
gene regulatory protein
RNA
cyclic AMP
PKA from binding to its nuclear import receptor
active
PKA
Which situation (s) described below would lead to an increase in the transcription of these target
genes? Mark yes or no for each of the following choices.
C
nuclear pore
activated target gene
TRANSCRIPTION
a mutation in the CREB gene that produces a protein that cannot be
a mutation in the nuclear import sequence of PKA that prevents
the enzyme unable to interact with the a subunit of the G protein
a mutation in the a unit of the G-protein that makes Ga unable to
a mutation in the gene that encodes adenylyl cyclase that renders
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