actin (A) junctional complex spectrin attachment proteins transmembrane proteins This conformation of actin shown in the figure above is very important for stabilizing the unique structure of the erythrocyte. O stepping stone conformation O ladder rungs conformation O hub and spoke conformation 100 nm O multiple array conformation
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- It is not an easy matter to assign particular func-tions to specific components of the basal lamina, sincethe overall structure is a complicated composite materialwith both mechanical and signaling properties. Nidogen,for example, cross-links two central components of thebasal lamina by binding to the laminin γ-1 chain and totype IV collagen. Given such a key role, it was surprisingthat mice with a homozygous knockout of the gene fornidogen-1 were entirely healthy, with no abnormal phe-notype. Similarly, mice homozygous for a knockout of thegene for nidogen-2 also appeared completely normal. Bycontrast, mice that were homozygous for a defined muta-tion in the gene for laminin γ-1, which eliminated just thebinding site for nidogen, died at birth with severe defectsin lung and kidney formation. The mutant portion of thelaminin γ-1 chain is thought to have no other functionthan to bind nidogen, and does not affect laminin struc-ture or its ability to assemble into the basal lamina.…The inner leaflet (monolayer) of the human erythrocyte membrane consists predominantly of phosphatidylethanolamine and phosphatidylserine. The outer leaflet consists predominantly of phosphatidylcholine and sphingomyelin. Although the phospholipid components of the membrane can diffuse in the fluid bilayer, this sidedness is preserved at all times. How?One of the important uses of the Nernst equation is in describing the flow of ions across plasma membranes. Ions move under the influence of two forces: the concentration gradient (given in electrical units by the Nernst equation) and the electrical gradient (given by the membrane voltage). This is summarized by Ohms law: Ix=Gx(VmEx) which describes the movement of ion x across the membrane. I is the current in amperes (A); G is the conductance, a measure of the permeability of x, in Siemens (S), which is I/V;Vm is the membrane voltage; and Ex is the equilibrium potential of ion x. Not only does this equation tell how large the current is, but it also tells what direction the current is flowing. By convention, a negative value of the current represents either a positive ion entering the cell or a negative ion leaving the cell. The opposite is true of a positive value of the current. a. Using the following information, calculate the magnitude of Na [ Na+ ]0=145mM,[ Na+ ]i=15mM,Gna+=1nS,Vm=70mV b. Is Na+ entering or leaving the cell? c. Is Na+ moving with or against the concentration gradient? Is it moving with or against the electrical gradient?
- There is an unusually high concentration of phosphatidylcholine on the lumenal side of the ER. What structural feature of phosphatidylcholine is responsible for this? Explainhow this structural feature produces this effectBriefly describe one voltage-gated ion channel and two protein pumps found in the heart. In your answer, you should explain how the voltage-gated ion channel responds to voltage changes and how it controls which ions pass through the channel. For the protein pumps, be sure to describe the structure of the protein pump and any conformational changes that it goes through. Additionally, you should briefly explain the importance of each ion channel or pump for the normal functioning of the cardiac muscle.pQLScB3CBS-8U2yQp5UAPJA-R3spS6YB8srqTGBoSwdXc_EattnA/viewform dvisor Main... My Drive - Google... Your answer What is the difference between primary active transport and secondary active transport? The sodium potassium pump * Job Listing - USF... WT Enrollment Requir... Is a symporter Can be blocked with drugs Controls intracellular chloride and potassium concentrations Is a glycolipid Breaks down ATP in order to generate energy ATP can be broken down to generate energy * True False A copy of your responses will be emailed to lc21-0506@lclark.edu. Submit Chemic Cle
- Carrier proteins may be open to both sides of the membrane at the same time True O FalseInhibin and activin are similar molecules; however they have very different physiological roles. Discuss these differences.The abundant intercellular connections gab junction can be found in O diaphragm O Heart muscle O Skeletal muscle O Smooth muscle
- The classic demonstration that cell plasma membranes are composed ofbilayers depends on the following kinds of data:• The membrane lipids from 4.74 x 109 erythrocytes will form a monolayerof area 0.89 m2 when spread on a water surface.• The surface of one erythrocyte is approximately 100 μm2 in area.Show that these data can be accounted for only if the erythrocyte membraneis a bilayer.What are found in animal hair andnails, as well as in cytokeratin filaments that associate withdesmosomes in epithelial cells to provide the cells and tissuewith strength.6) Consider the mechanism of net NaCl secretion across an epithelium shown below (in attachment) What provides the driving force for Cl- entry through the basolateral membrane into cell?