A toxin released by a nasty bacterium forces the cell to undergo apoptosis. Which of the following events would the toxin NOT use to promote cell death? Promoting Fas receptor activity Suppressing Apaf expression Release of cytochrome C into the cytoplasm Suppressing flippase activity O Promoting cleavage of caspase proteins
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Apoptosis is a programmed cell death process in which the cell's contents are packaged into small packets of membrane for “garbage collection” by immune cells. Apoptosis removes cells during development, eliminates potentially cancerous and virus-infected cells, and maintains balance in the body. Biochemical events lead to characteristic cell changes and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, chromosomal DNA fragmentation, and global mRNA decay.
Fas receptor activity enhancement leads to apoptosis through Fas mediated ligand pathway. Hence the first option is incorrect.
Suppressing Apaf expression leads to stopping of intrinsic apoptotic pathway. Hence the second option is correct.
Cytochrome C is released during intrinsic apoptotic pathway from the mitochondrion for the initiation of pathway. Hence the third option is incorrect.
Suppressing flippase activity promotes cell death. Hence the fourth option is incorrect.
Promoting cleavages of caspase leads to cell death. Hence the fifth option is incorrect.
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