Why is the Ras small GTPase so dangerous when it is no longer able to hydrolyze GTP to GDP? O A CTD will build un to toxie coneentrotione within the ooll ond trigger pooretio ooll deoth

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Why is the Ras small GTPase so dangerous when it is no longer able to hydrolyze GTP to GDP?
O A. GTP will build up to toxic concentrations within the cell and trigger necrotic cell death.
B. Ras-GTP will persist in the cell and trigger out of control cell proliferation.
C. Phosphodiesterase will be inhibited and prevent PKA activation.
D. Ras will no longer be able to efficiently bind to its downstream effectors in the crowded cytoplasm.
Transcribed Image Text:Why is the Ras small GTPase so dangerous when it is no longer able to hydrolyze GTP to GDP? O A. GTP will build up to toxic concentrations within the cell and trigger necrotic cell death. B. Ras-GTP will persist in the cell and trigger out of control cell proliferation. C. Phosphodiesterase will be inhibited and prevent PKA activation. D. Ras will no longer be able to efficiently bind to its downstream effectors in the crowded cytoplasm.
Protein scaffolds are an important part of intracellular signaling following activation of receptors on the cell membrane. This is
because scaffolds
A. cause conformational changes in G proteins
B. help proteins find each other to transmit signals in the dense cytoplasm
C. initiate positive feedback loops to alter protein levels in the cytoplasm
D. lead to changes in protein synthesis
Transcribed Image Text:Protein scaffolds are an important part of intracellular signaling following activation of receptors on the cell membrane. This is because scaffolds A. cause conformational changes in G proteins B. help proteins find each other to transmit signals in the dense cytoplasm C. initiate positive feedback loops to alter protein levels in the cytoplasm D. lead to changes in protein synthesis
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Step 1

RAS protein 

RAS proteins are small group of GTPase which main function is to transmit signals within the cells. 

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