The completely synthetic yeast chromosome Syn IIIcontains a loxP site in the 3′ UTR of every gene thatis potentially nonessential to yeast survival. As youwill recall from Chapter 6, loxP sites are targets ofsite-specific recombination. The researchers who constructed Syn III included these loxP sites as a way to“scramble” the chromosome, meaning that parts ofthe chromosome could easily be deleted or rearranged.The goal of these investigations is to drive the evolution of Syn III so as to define a minimal genome thatcan support the life of this organism. Outline the experiment the researchers would do to scramble Syn IIIin order to define a minimal genome.

Human Anatomy & Physiology (11th Edition)
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Author:Elaine N. Marieb, Katja N. Hoehn
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Chapter1: The Human Body: An Orientation
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The completely synthetic yeast chromosome Syn III
contains a loxP site in the 3′ UTR of every gene that
is potentially nonessential to yeast survival. As you
will recall from Chapter 6, loxP sites are targets of
site-specific recombination. The researchers who constructed Syn III included these loxP sites as a way to
“scramble” the chromosome, meaning that parts of
the chromosome could easily be deleted or rearranged.
The goal of these investigations is to drive the evolution of Syn III so as to define a minimal genome that
can support the life of this organism. Outline the experiment the researchers would do to scramble Syn III
in order to define a minimal genome.

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