The Commercial Trainee Program of the Pharma Biotec Industry, opened selection to admit candidates who would help in the development of a more efficient production protocol of Ibuprofen, a non-colloidal anti-inflammatory. Basically, the challenge stimulated obtaining high enantiomeric purity of the final product. In this way, the candidates proposed the use of immobilized enzymes for the process. Tick the most coherent alternative to justify the choice of using immobilized enzymes by the candidates for the case mentioned above in the question. (Only one statement is true)* A)The use of immobilized enzymes was an interesting strategy, since different immobilization techniques can be used, such as adsorption and covalent. b) The use of immobilized enzymes was consistent since the immobilization process can further favor the regioselectivity , enantioselectivity and stereoselectivity properties of the enzymes, which will favor the enantiomeric purity of the drug. c) The use of immobilized enzymes is interesting because the biocatalyst can be reused. d) The use of immobilized enzymes is preferred to the use of immobilized cells due to the low cost of the selected supports. e) The use of immobilized enzymes favors the protein conformation of the protein within the support, favoring high drug conversion. f) The use of immobilized enzymes helps in the economy of the

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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The Commercial Trainee Program of the Pharma Biotec Industry, opened selection to admit candidates who would help in the development of a more efficient production protocol of Ibuprofen, a non-colloidal anti-inflammatory. Basically, the challenge stimulated obtaining high enantiomeric purity of the final product. In this way, the candidates proposed the use of immobilized enzymes for the process. Tick the most coherent alternative to justify the choice of using immobilized enzymes by the candidates for the case mentioned above in the question. (Only one statement is true)* A)The use of immobilized enzymes was an interesting strategy, since different immobilization techniques can be used, such as adsorption and covalent. b) The use of immobilized enzymes was consistent since the immobilization process can further favor the regioselectivity , enantioselectivity and stereoselectivity properties of the enzymes, which will favor the enantiomeric purity of the drug. c) The use of immobilized enzymes is interesting because the biocatalyst can be reused. d) The use of immobilized enzymes is preferred to the use of immobilized cells due to the low cost of the selected supports. e) The use of immobilized enzymes favors the protein conformation of the protein within the support, favoring high drug conversion. f) The use of immobilized enzymes helps in the economy of the process. g) The use of immobilized enzymes is more coherent than the use of organic synthesis, since the supports would not resist organic solvents. h) The use of immobilized enzymes was a mistake in choosing candidates as it will not result in enantiomeric purity.

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