You are working for a drug discovery company. Your team has identified a derivative (you will be given a randomly selected compound from the table below) of aspirin/paracetamol, has optimal physicochemical properties for biological activity. To conduct preliminary tests on the drug candidate you are required to synthesise the derivative from benzene. Propose a synthetic pathway starting from benzene to the candidate drug. Important: your company wants efficiency, a synthetic, pathways that provide good yield (major product) and are energy efficient (if possible, avoid pathways that involve working with lots of ring deactivating groups) is preferred. H3CO. HO S

You are working for a drug discovery company. Your team has identified a derivative (you will be given a randomly selected compound from the table below) of aspirin/paracetamol, has optimal physicochemical properties for biological activity. To conduct preliminary tests on the drug candidate you are required to synthesise the derivative from benzene. Propose a synthetic pathway starting from benzene to the candidate drug. Important: your company wants efficiency, a synthetic, pathways that provide good yield (major product) and are energy efficient (if possible, avoid pathways that involve working with lots of ring deactivating groups) is preferred. H3CO. HO S