Suppose that Protein J which is a hypothetical protein kinase receptor was determined tobe related to the progression of cancer through its activation. It was also determined that theprotein exists in the active and inactive forms. The said active form is highly similar to the ProteinK's conformation. Ligands A, B, and C, which are lead inhibitor compounds, were optimized toinhibit Protein J. The affinities of the ligands are shown in the table.Kp valuesActive Protein JInactive Protein JProtein KLigand A10 mM20 nM5 mMLigand B20 nM10 mM15 nMLigand C20 nM15 nM15 nMQuestion:a. Which of the ligands, based on the table, has the highest specificity in binding to thetarget Protein J?

Ligand is a molecule that binds to the biomolecule and forms a complex. In ligand-protein binding,…

Answered: Suppose that Protein J which is a…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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From the Hill Plot below, the of the first binding event for the receptor-ligand system under study is: Q1 4nM Ο 10 μΜ -2 nM 2 nM Calculate the Hill Coefficient from the receptor-ligand binding data below: Q2 4 100 2 3 (0-1) 60 log 10 8 6 4 2 0 -2 -4 -6 -6 -4 -2 0 2 4 log [L] (nM) 6 8 10
Need help Intaractions of FAK kinase which directly depend on the tyrosine residue 397 (Y397) are inhibbited by a chemical compound in cancercells. Intaraction of FAK kinase with what proteins are blocked by this inhibition? (please give a listt of them all, and that's it)
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The Graph below shows the binding curves of two proteins (A and B) for the same ligand (L). Use this Graph and determine the dissociation constant, K, for both proteins. Which protein (A or B) has a greater affinity for ligand L? Which of the two proteins would be more easily inhibited by an antagonist? 1.0 Y 0.5 2 A 4 6 B 8 [L] (μM) 10 12 14 16
ras GDP ras ras P.P P.P GTP raf Inactive Active raf Inside of cell Refer to the figure above. A portion of a signal transduction pathway is shown in the figure. The molecule raf is a protein kinase. This molecule becomes activated when a GTP-ras complex binds to it. Which equation describes how activated raf transmits the signal in this pathway? O ATP. --> CAMP +PPi O CAMP --> AMP Inactive enzyme + ATP --> active phosphorylated enzyme + ADP O Inactive phosphorylated enzyme + ADP --> inactive enzyme + ATP Inactive enzyme + ADP --> active phosphorylated enzyme + ATP Assessment Navigator Submit Questionmark Ondemand licensed to University of Dundee PPIP
What are the primary structures of the 1AWJ tyrosine kinase enzyme? What are the secondary structures of the 1AWJ tyrosine kinase enzyme? What is the property of tyrosine kinase enzymes?
Same question but two different sections

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