What exists as a dimer in which the α-subunit con-tains a trapped and nonhydrolyzable GTP and the β-subunit binds an exchangeable and hydrolyzable GTP.
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A:
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What
exists as a dimer in which the α-subunit con-
tains a trapped and nonhydrolyzable GTP and the β-subunit
binds an exchangeable and hydrolyzable GTP.
Step by step
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- Some protein kinases are inactive unless they are phosphorylated on key serine or threonine residues. In some cases, active enzymes can be generated by mutating these serine or threonine residues to aspartate. Explain.Synthesis of peptide bonds is [exorgonic or endergonic]. Thus in isolation, this reaction would [occur or not occur] in cells. Peptide synthesis at the ribosome is coupled to GTP hydrolysis which is an [exergonic or endergonic] process thus making the overall process of synthesizing peptides [spontaneous or not spontaneous].In trimetric G proteins the only function of the bamma y complex is to allow reactivating of the a subunit ? True or false
- The A subunit of cholera toxin causes the cAMP-mediated opening of chloride channels. A massive diarrhea results because the GTP hydrolysis of GTP-αs is prevented. Describe why this inhibition leads to the diarrhea.Some protein kinases are inactive unless they are phosphorylated on key serine or threonine residues. In some cases, active enzymes can be generated by mutating these serine or threonine residues to glutamate. Explain. What could you predict about a mutant generated replacing the serine or threonine with alanine.AAAGAGAAAAGAAUA to AAAGAGAAAUGAAUA. Suppose the codon sequence has a single base pair mutation If the old protein sequence was Lys-Glu-Lys-Arg-Ile, what will be the new sequence encoded by the mutant gene? (Use the 3-letter amino acid abbreviations with hyphens and no spaces in between, i.e. Ser-Asn-Tyr-Leu-Pro.) Submit Answer Retry Entire Group No more group attempts remain
- True or False Activation of a G protein complex causes a conformational change in the α subunit, allowing GDP to be replaced by GTPThe protein fragments ABS1 and ABS2 of tropomodulin were produced as fusion proteins with chitin binding domain and purified by a chitin column. Explain the principles of this type of affinity chromatography and support it with a self‐drawn figure. This is with regards to Tropomodulin/ F-Actin complex.A binding curve for the binding of the amino acid tryptophan to the protein called TxtE is shown below. Estimate the association equilibrium constant (Ka; in units of M-1) for Trp binding to TxtE.
- prpc is a normal protein of our neuronal cell membrane that is sensitive to protease action (ie can be broken down by protease) true or false?Ribosomes markedly accelerate thehydrolysis of GTP bound to the complex of EF-Tu and aminoacyltRNA. What is the biological significance ofthis enhancement of GTPase activity by ribosomes?Crystal structures exist for three neurokinin-1 (NK1) ligand complexes with the following pdb codes (6hll, 6hlo, 6hlp) For each of the three crystal structures identify four amino acids in the NK1 binding site that contact the ligand indicating both the residue type in three letter code and the residue number. One of the chose amino acids should form a hydrogen binding interaction to the ligand, state which functional group the amino acid utilises in each case