Pyruvate dehydrogenase kinase is a deffected enzyme and it is the connection between the alteration of metabolism and cancer.  How the structure and action of this deffective enzyme/protein are altered or essential. This may include the regulation of this protein, its rate of synthesis, importance in rapid cell growth, etc

Human Physiology: From Cells to Systems (MindTap Course List)
9th Edition
ISBN:9781285866932
Author:Lauralee Sherwood
Publisher:Lauralee Sherwood
Chapter2: Cell Physiology
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Pyruvate dehydrogenase kinase is a deffected enzyme and it is the connection between the alteration of metabolism and cancer. 

  1. How the structure and action of this deffective enzyme/protein are altered or essential. This may include the regulation of this protein, its rate of synthesis, importance in rapid cell growth, etc.
  2. How does this alteration lead to cancer, enhance the survival of a cancerous cell, etc.?
  3. Any pharmaceutical treatments that are in development to target this protein, along with their biochemical basis. Draw the chemical structures of any drugs that are discuss as well as their mechanism of action.  
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