Point mutations in multiple tumor suppressor proteins have been linked to cancer. For example changes in the gene for adenomatous-polyposis-coli protein (APC gene) may result in colorectal cancer. Consider the following DNA sense strand. 3'-TAC CGG TTG TGA AGC TGA ATC-5'

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A: p53 Mutations are a Frequent Event in Cancer:--The evolution in a normal cell producing cancerous…

Q: Telomerase is an attractive cancer target since 85% - 90% of tumors express telomerase (while normal…

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A: INTRODUCTION A bacteriophage, or phage for brief , is a virus that infects bacteria. Like other…

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A: PDGF is naturally synthesized and stored by the body. Its primary role is to encourage the growth…

Q: Why is it important to model cancer through the generation of induced pluripotent stem cells ?…

A: Induced pluripotent stem cells (iPS) is a type of stem cell(pluripotent) in nature that is derived…

Q: Cancer cells generally have missense mutations in p53 gene, resulting in truncated p53 normally…

A: A normal cell is converted into a cancer cell when the there is deactivation of the tumor suppressor…

Q: Why is it important to model cancer through the generation of induced pluripotent stem cells ?…

A: Medical technology has advanced significantly over the course of many centuries. According to…

Q: Why is it important to model cancer through the generation of induced pluripotent stem cells ?…

A: Genetic transformation happens when the genetic composition of an organism is transformed by the…

Q: Heterotypic interactions of tumor cells have been a fertile area for potential therapeutic…

A: Cancer is a major disorder and it causes development of abnormal cells & they divide…

Q: Sequences of DNA that are in Signal Joint are responsible for recombination event in somatic cells…

A: The group of organs that protect the body from various pathogens constitute the immune system. They…

Q: Explain why mutations in tumor suppressor genes are recessive (both copies of the gene must be…

A: Mutation in an organism is defined as a permanent alteration of “nucleotide sequences”. The…

Q: (a) Identify both the cellular component and the location of the component that is responsible for…

A: Luciferase reporter produces luminescence. If cells contain a luciferase vector, the luminescent…

Q: Explain the role of p53 protein in protecting normal cells against cancer. With respect to this…

A: The cell is the primary unit of all living entities. The normal cell undergoes some necessary…

Q: discuss the Role of telomere in disease  Provide detailed examples

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Q: Mutations in the RB gene are often associated with cancer. Explain how a mutation that results in a…

A: The cell cycle is the series of stages that allow the cell to pass from one cell division to…

Q: Mention the causative agents of DNA lesions in the human body that can lead to cancer.

A: The causative agents are environmental agents that alter the structure of DNA and lead to harmful…

Q: Prompts Gain of function. Oncogenes Mutated forms of proto-oncogenes Examples of oncogenes Loss of…

A: cancer is caused by a mutation in genes it is heridatory Generally due to by chance in the genes to…

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Q: You have two patients with pancreatic cancer. Patient 1 has a KRAS oncogenic mutation; a myc…

A: Answer a : - CBP-93872 is the most effective in patients having loss of function mutation for tumour…

Q: Cancer is caused by many different types of gene mutations. Some mutations are in proto-oncogenes,…

A: Cells split into new cells so that the body uses them and cancer starts with this wonderful…

Q: Describe the differences between point mutations, chromosomal translocations, and gene amplification…

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Q: Describe how mutations in genome maintenance factors promote tumorigenesis. Why would inactivation…

A: The cells are basic units of life. When any mutation in the gene takes place due to any radiation or…

Q: xplain the data below and why knockout of Angpt2, MMP3 and MMP10 appears to inhibit metstastasis.

A: MMP stands for matrix metalloproteinase is a multi-functional factor that plays a crucial role in…

Q: The p53 gene is a tumor-suppressor gene while Ras is a proto-oncogene. Mutation in either one can…

A: Tumor suppressor genes are the genes that are involved in various checkpoints in the cell cycle,…

Q: Explain why p53 is mutated in the vast majority of human cancers.

A: Any isoform of a protein encoded by homologous genes in multiple animals, such as TP53 and Trp53, is…

Q: Name one type of gene that leads to cancer when it is mutated

A: All malignant growth which is called as cancer also is the consequence of mutation in gene. Changes…

Q: Explain why many oncogenic viruses contain genes whose products interact with tumor-suppressor…

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Q: The p53 gene is a tumor-suppressor gene while p634  gene is an oncogene. Mutation in either one can…

A: Cancer is a disease in which some of the body’s cells grow uncontrollably and spread to other parts…

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Q: Briefly describe the structural variability of cancer genomes.

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Q: Please distinguish driver and passenger mutations in cancer.

A: Driver mutations: Mutations in known oncogenes that help cells establish or maintain the transformed…

Q: What separates cancer cells from normal cells?

A:

Q: Explain in general what is meant by a proto-oncogene and how they are involved in the formation of a…

A: Proto-oncogenes are a bunch of normal genes present in a cell. They have the necessary information…

Q: Based on the data provided, explain how cellular processes must be altered in stomach cancer cells…

A: In comparison to healthy cells, cancer cells have an active metabolism and need more energy. Cancer…

Q: during tumor progression, additional mutations occur within multiple cells of a tumor population,…

A: Tumor progression is a phase of tumor development which is characterized by increased growth speed…