RG, a 6-year-old child, has been diagnosed with Acute Lymphoblastic Leukemia (ALL). The standard treatment is 6-mercaptopurine (Purinethol), an inexpensive drug that inhibits proliferation and is effective against rapidly proliferating cells like cancer cells. The compound is an antimetabolite that interferes with DNA synthesis. However, about 10% of patients experience life-threatening toxicities. 6-mercaptopurine is metabolized and detoxified by the enzyme thiopurine-S-methyltransferase (TPMT). The most common SNPS correlated with low enzymatic activity are TPMT*3A, *3B, *3C and *2. They cause enhanced degradation of the enzyme. Genotyping reveals that RG has the following genotype: TPMT*3A/*2. Questions: A patient with TPMT*1/*1 should receive what kind of dose? Reduced dose Standard dose Increased dose
RG, a 6-year-old child, has been diagnosed with Acute Lymphoblastic Leukemia (ALL). The standard treatment is 6-mercaptopurine (Purinethol), an inexpensive drug that inhibits proliferation and is effective against rapidly proliferating cells like cancer cells. The compound is an antimetabolite that interferes with DNA synthesis. However, about 10% of patients experience life-threatening toxicities. 6-mercaptopurine is metabolized and detoxified by the enzyme thiopurine-S-methyltransferase (TPMT). The most common SNPS correlated with low enzymatic activity are TPMT*3A, *3B, *3C and *2. They cause enhanced degradation of the enzyme. Genotyping reveals that RG has the following genotype: TPMT*3A/*2. Questions: A patient with TPMT*1/*1 should receive what kind of dose? Reduced dose Standard dose Increased dose
Chapter8: Forms Of Drugs And How They Act
Section: Chapter Questions
Problem 27RQ
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![RG, a 6-year-old child, has been diagnosed with Acute Lymphoblastic Leukemia (ALL). The
standard treatment is 6-mercaptopurine (Purinethol), an inexpensive drug that inhibits
proliferation and is effective against rapidly proliferating cells like cancer cells. The compound is
an antimetabolite that interferes with DNA synthesis. However, about 10% of patients
experience life-threatening toxicities. 6-mercaptopurine is metabolized and detoxified by the
enzyme thiopurine-S-methyltransferase (TPMT). The most common SNPS correlated with low
enzymatic activity are TPMT*3A, *3B, *3C and *2. They cause enhanced degradation of the
enzyme. Genotyping reveals that RG has the following genotype: TPMT*3A/*2.
Questions:
A patient with TPMT*l/*1 should receive what kind of dose?
Reduced dose
Standard dose
Increased dose](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F3b627685-f78e-4699-ad83-d7506eed7160%2Fad53ee39-0cf5-4bbf-98e2-bb0fe49b8d09%2Fnzyuwl_processed.png&w=3840&q=75)
Transcribed Image Text:RG, a 6-year-old child, has been diagnosed with Acute Lymphoblastic Leukemia (ALL). The
standard treatment is 6-mercaptopurine (Purinethol), an inexpensive drug that inhibits
proliferation and is effective against rapidly proliferating cells like cancer cells. The compound is
an antimetabolite that interferes with DNA synthesis. However, about 10% of patients
experience life-threatening toxicities. 6-mercaptopurine is metabolized and detoxified by the
enzyme thiopurine-S-methyltransferase (TPMT). The most common SNPS correlated with low
enzymatic activity are TPMT*3A, *3B, *3C and *2. They cause enhanced degradation of the
enzyme. Genotyping reveals that RG has the following genotype: TPMT*3A/*2.
Questions:
A patient with TPMT*l/*1 should receive what kind of dose?
Reduced dose
Standard dose
Increased dose
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