RG, a 6-year-old child, has been diagnosed with Acute Lymphoblastic Leukemia (ALL). The standard treatment is 6-mercaptopurine (Purinethol), an inexpensive drug that inhibits proliferation and is effective against rapidly proliferating cells like cancer cells. The compound is an antimetabolite that interferes with DNA synthesis. However, about 10% of patients experience life-threatening toxicities. 6-mercaptopurine is metabolized and detoxified by the enzyme thiopurine-S-methyltransferase (TPMT). The most common SNPS correlated with low enzymatic activity are TPMT*3A, *3B, *3C and *2. They cause enhanced degradation of the enzyme. Genotyping reveals that RG has the following genotype: TPMT*3A/*2. Questions: A patient with TPMT*1/*1 should receive what kind of dose? Reduced dose Standard dose Increased dose

RG, a 6-year-old child, has been diagnosed with Acute Lymphoblastic Leukemia (ALL). The standard treatment is 6-mercaptopurine (Purinethol), an inexpensive drug that inhibits proliferation and is effective against rapidly proliferating cells like cancer cells. The compound is an antimetabolite that interferes with DNA synthesis. However, about 10% of patients experience life-threatening toxicities. 6-mercaptopurine is metabolized and detoxified by the enzyme thiopurine-S-methyltransferase (TPMT). The most common SNPS correlated with low enzymatic activity are TPMT3A, 3B, 3C and 2. They cause enhanced degradation of the enzyme. Genotyping reveals that RG has the following genotype: TPMT3A/2. Questions: A patient with TPMT1/1 should receive what kind of dose? Reduced dose Standard dose Increased dose

Principles Of Pharmacology Med Assist

6th Edition

ISBN:9781337512442

Author:RICE

Publisher:RICE

Chapter8: Forms Of Drugs And How They Act

Section: Chapter Questions

Problem 27RQ

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