methyltransferase (TPMT) levels is correct? 27. In the context of 6-mercaptopurine (6-MP) therapy for leukemia, which statement about thiopurine A) High TPMT levels are associated with increased sensitivity to 6-MP and higher risk of adverse reactions. B) Low TPMT levels are associated with increased sensitivity to 6-MP and higher risk of adverse reactions decreased therapeutic efficacy C) High TPMT levels result in reduced metabolism of 6-MP, leading to D) Low TPMT levels result in increased metabolism of 6-MP, leading to excessive drug accumulation and toxicity.
methyltransferase (TPMT) levels is correct? 27. In the context of 6-mercaptopurine (6-MP) therapy for leukemia, which statement about thiopurine A) High TPMT levels are associated with increased sensitivity to 6-MP and higher risk of adverse reactions. B) Low TPMT levels are associated with increased sensitivity to 6-MP and higher risk of adverse reactions decreased therapeutic efficacy C) High TPMT levels result in reduced metabolism of 6-MP, leading to D) Low TPMT levels result in increased metabolism of 6-MP, leading to excessive drug accumulation and toxicity.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Transcribed Image Text:27. In the context of 6-mercaptopurine (6-MP) therapy for leukemia, which statement about thiopurine
methyltransferase (TPMT) levels is correct?
A) High TPMT levels are associated with increased sensitivity to 6-MP and higher risk of adverse
reactions.
B) Low TPMT levels are associated with increased sensitivity to 6-MP and higher risk of adverse
reactions
C) High TPMT levels result in reduced metabolism of 6-MP, leading to decreased therapeutic efficacy
D) Low TPMT levels result in increased metabolism of 6-MP, leading to excessive drug accumulation
and toxicity.
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