Acquired mutation in the p53 gene is the most common genetic alteration found in human cancer (> 50% of all cancers). A germline mutation in p53 is the causative lesion of Li- Fraumeni familial cancer syndrome. In many tumors, one p53 allele on chromosome 17p is deleted and the other is mutated. What type of protein is encoded by the p53 gene? (A) Caspase (B) DNA repair enzyme (C) Membrane cell adhesion molecule (D) Serine phosphatase (E) Telomerase (F) Transcription factor (G) Tyrosine kinase

Q: The protein p53 is activated when the cell's DNA is damaged. p53 helps to arrest the cell cycle in…

A: Cell division is controlled by a protein that is encoded by a tumor suppressor gene. Uncontrolled…

Q: The p53 gene was discovered in 1979, but it was not clear whether the gene functioned as an oncogene…

A: An oncogene is a type of gene that is responsible for causing the cells to divide uncontrollably and…

Q: In a few sentences, describe how p53 guards the genome. Include at least two specific ways that p53…

A: The TP53 ( Tumor protein 53) also known as P53. This gene codes for cell cycle regulatory proteins…

Q: Which genetic cancer predisposition syndrome is caused by germ-line mutations in the p53 gene and is…

A: P53 is the tumor suppressor protein (TP53 in humans) which is also described as the guardian of the…

Q: Activation of p53 during cellular stress will generally Select one: o a. Increase transcription of…

A: P553 is a tumor suppressor gene.

Q: Although each cell in your body contains the same set of genes, the genes that are “turned on”…

A: DISCLAIMER FOR MULTIPLE   Since you have asked multiple question, we will solve the first question…

Q: Cancer is a major public health problem.  Both inherited genes and environmental factors play a role…

A: Cancer has become a major global health issue for some time. Cancers occur by environmental…

Q: MSH2 is a gene commonly associated with HNPCC (Hereditary nonpolyposis colorectal cancer). This gene…

A: Hereditary nonpolyposis colorectal cancer (HNPCC), also known as Lynch syndrome, is an inherited…

Q: A mutated form of protein p5x is found in patients with squamous cell carcinoma. In vitro studies…

A: A gene that produces a protein that is essential for regulating cell division and death and is…

Q: Most forms of cancer are caused by environmental agents that produce mutations in somatic cells. Is…

A: Environmental factors have been known to trigger a lot of the mutations which develop into cancerous…

Q: The phenotype of a heterozygous mouse (Aa) is agouti.  The agouti banding pattern is due to altered…

A: * Homozygous dominant and Heterozygous will produce agouti that is AA or Aa respectively  and the…

Q: Describe error prone polymerases and the process of translesion synthesis (TLS). In regards to tumor…

A: Translesion synthesis (TLS) is a method of overcoming stopped replication in which particular…

Q: What is cancer? What defects are commonly found in cancer cells? Do all cancer cells have mutations…

A: Cancer is a group of diseases characterized by the uncontrolled growth and spread of abnormal cells…

Q: Mutations in proto-oncogenes that turn them into oncogenes tend to be dominant, while cancer-causing…

A: Tumor suppressor genes are the genes that suppress the formation of tumors in the cells or tissues…

Q: Explain why p53 is mutated in the vast majority of human cancers.

A: Any isoform of a protein encoded by homologous genes in multiple animals, such as TP53 and Trp53, is…

Q: The mutation associated with pancreatic cancer in the family in Figure23.1 was located in an exon of…

A: Mutation is a change in the sequence of genetic material either due to a mistake in replication or…

Q: Describe the effects of the mutation causing the p21 promoter to no longer bind p53 on cell…

A: p53 is a tumor suppressor gene but if p53 gets mutated then this protein is not able to bind to the…

Q: The P63 and P53 have similar functionalities in the cell, however, p53 is rarely associated directly…

A: Tumor protein 63 (p63) could also be a transcription factor of the p53 gene family encoded by the…

Q: Do you think there are more unique alleles of p53 that lead to cancer or more unique alleles of Ras…

A:

Q: Create a graph as a better way to display the data in the table 2) Determine which mutations (5q,…

A: Tumorigenesis or oncogenesis refers to the initial formation of cancer, where normal cells is prone…

Q: You are analyzing the activity of the protein p53 in two different cell types. You notice that p53…

A: The function of a protein is primarily related to its structure if the composition of protein is…

Q: Patients with XP suffer extremely high incidence of skin cancer but have not been found to have…

A: There are 2 basic types of genetic mutations: Acquired mutations.  These are the most common causes…