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Patients suffering from Familial Hypercholesterolemia (FH) can carry a mutation in one of several genes. Two of these genes are ApoB and PCSK9. a. Diagram the normal cholesterol sensing pathway for a healthy person. This should be focused on the molecules that handle cholesterol and that regulate cholesterol production, NOT on patient symptoms. b. On your diagram indicate where a mutation in ApoB disrupts cholesterol sensing. Then write a paragraph or two explaining how cholesterol sensing is specifically disrupted in patients with an ApoB mutation. c. On your diagram indicate where a mutation in PCSK9 disrupts cholesterol sensing. Then write a paragraph or two explaining how cholesterol sensing is specifically disrupted in patients with PCSK9 mutation. -

Patients suffering from Familial Hypercholesterolemia (FH) can carry a mutation in one of several genes. Two of these genes are ApoB and PCSK9. a. Diagram the normal cholesterol sensing pathway for a healthy person. This should be focused on the molecules that handle cholesterol and that regulate cholesterol production, NOT on patient symptoms. b. On your diagram indicate where a mutation in ApoB disrupts cholesterol sensing. Then write a paragraph or two explaining how cholesterol sensing is specifically disrupted in patients with an ApoB mutation. c. On your diagram indicate where a mutation in PCSK9 disrupts cholesterol sensing. Then write a paragraph or two explaining how cholesterol sensing is specifically disrupted in patients with PCSK9 mutation. -

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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5. Patients suffering from Familial Hypercholesterolemia (FH) can carry a mutation in one of several genes. Two of these genes are ApoB and PCSK9. 6 a. Diagram the normal cholesterol sensing pathway for a healthy person. This should be focused on the molecules that handle cholesterol and that regulate cholesterol production, NOT on patient symptoms. b. On your diagram indicate where a mutation in Apoß disrupts cholesterol sensing. Then write a paragraph or two explaining how cholesterol sensing is specifically disrupted in patients with an Apoß mutation. c. On your diagram indicate where a mutation in PCSK9 disrupts cholesterol sensing. Then write a paragraph or two explaining how cholesterol sensing is specifically disrupted in patients with PCSK9 mutation. A in cancers. One approach focuses on the
Transcribed Image Text:5. Patients suffering from Familial Hypercholesterolemia (FH) can carry a mutation in one of several genes. Two of these genes are ApoB and PCSK9. 6 a. Diagram the normal cholesterol sensing pathway for a healthy person. This should be focused on the molecules that handle cholesterol and that regulate cholesterol production, NOT on patient symptoms. b. On your diagram indicate where a mutation in Apoß disrupts cholesterol sensing. Then write a paragraph or two explaining how cholesterol sensing is specifically disrupted in patients with an Apoß mutation. c. On your diagram indicate where a mutation in PCSK9 disrupts cholesterol sensing. Then write a paragraph or two explaining how cholesterol sensing is specifically disrupted in patients with PCSK9 mutation. A in cancers. One approach focuses on the
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