A contributing factor to the development of arthritis is the inappropriate proteolytic destruction of the aggrecan component ofcartilage by the proteolytic enzyme aggrecanase. The immune system signal molecule interleukin 2 (IL-2) activatesaggrecanase; in fact, IL-2 blockers are sometimes used to treat arthritis.Studies were undertaken to determine whether inhibitors of aggrecanase could counteract the effects of IL-2. Pieces ofcartilage were incubated in media with various additions and the amount of aggrecan destruction was measured as a functionof time.What is the effect of adding IL-2 to the system?Aggrecan degradation remains the same.Aggrecanase activity is greatly reduced.Aggrecan degradation is greatly reduced.Aggrecan degradation is greatly enhanced.What is the response when an aggrecanase inhibitor is added in addition to IL-2?O Aggrecan degradation remains the same as when IL-2 was added.Aggrecan degradation completely stops.Aggrecan degradation is reduced to the background system level.Aggrecan degradation is further enhanced.

Enzymes are proteins that catalyse biochemical reactions. An enzyme's activity is a reference to the…

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Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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