15. The deficiency of glucose-6-phosphate dehydrogenase (G6PD) is one of themost common inborn errors of metabolism worldwide. This congenital disordergenerally results from mutations that are spread throughout the entire geneof G6PD. Three mutations for G6PD, AAAAGAGGG AAACAUGGG,„CACAAUCAC-CACCAUCAC, AUGACUAAA AUGGCUAAA areresponsible for severe deerease of the protein activity. What types of mutationsare these? To answer the question please:I) explain what the mutation is;2) describe the types of mutation you know;3) explain the difference between germline and somatic mutatiymem

There are three main components in our body that help us to store and express the information within…

Answered: of G6PD. Three mutations for G6PD,…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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GQ11
Drug 2-Lumacaftor (VX-809): In people with the most common CF mutation, F508del, a series of problems prevents the CFTR protein from folding into the correct shape and reaching its proper place on the cell surface. The cell recognizes the protein as abnormal and targets it for degradation before it makes it to the cell surface. In order to treat this problem, two drugs are required - an agent to get the protein to the surface and then Ivacaftor to open the channel and increase chloride transport. The drug Lumacaftor has been identified as a treatment to help with the trafficking of the protein to the cell surface. When Lumacaftor is added to Ivacaftor, the protein gets to the surface and also increases chloride transport by increasing channel opening time. For which class(es) of mutations would Lumacaftor be most effective?
Please help. An explanation will be very helpful. Thank you
Q38. The ΔF508 mutation of the CFTR gene is the cause of most cases of cystic fibrosis (CF). One focus of research into a cure for CF is "gene therapy" — inserting normal copies of the CFTR gene into the cells of CF patients. Which of the following areas of CF research is most likely to improve symptoms for CF patients? A. Inserting extra copies of genes that code for the proteosome. B. Studying the chaperone proteins of the endoplasmic reticulum (ER). C. Improving the lung function of people who are carriers of the CF allele (Cc). D. Stabilizing the plasma membrane were the ΔF508 form of the protein accumulates.
5. (a) Hexokinase IV is known as glucokinase (GCK) and is a central metabolic enzyme that participates in glucose homeostatic maintenance by governing the rates of glucose catabolism in pan- creatic B-cells and glycogen storage in hepatocytes (liver cells). In contrast to the regulatory mecha- nisms of hexokinase I or Il in other tissues, GCk is regulated by binding to the Glucokinase Regulatory Protein (GRP) located in the cell nucleus. When glucose in hepatocytes is low, GCK is sequestered in the nucleus by binding to the GRP. High glucose, for instance, after ingestion of a meal, disrupts the GRP-GCK complex, allowing the GCK to diffuse into the cytoplasm to convert glucose into glucose-6- phosphate. Contrast the properties of hexokinases I and IV with respect to oligomeric structure, mech- anism of regulation of their activity, KM value, and dependence of catalytic activity on cellular location. Hexokinase l is found in, for instance, muscle tissue. Property subunit structutre…
please answer question number 5 asap.
. What physiological effect would you predict from a mutation that replaced with serine the cysteine in the constant part of the immunoglobulin light chain that is involved in disulfide-bond for- mation with the heavy chain? ,
77. During a study of primary human hepatocytes, it is found that these cells dedifferentiate when grown in culture and lose many of the synthetic and metabolic functions unique to in vivo hepatocytes. Coculturing the primary hepatocytes with biliary epithelial cells preserves many aspects of the differentiated state of the hepatocytes. Compared with hepatocytes grown alone, the cocultured hepatocytes most likely produce an increased amount of which of the following? A) Alanine B) Fructose C) Maltose D) Pyruvate E) Urea
Severe adverse effect of Tocilizumab and Dexamethasone in COVID19 ?
short answer please! thank you!
Cell and Molecular Biology Subject: 1. Explain how the actions of the lac operon are different from the trp operon. 2. Why is it important for a multicellular organism to be able to turn on only some of its genes in any particular tissue or cell type?
True or False. 1. a.) RNA polymerase decodes mRNA so the ribosome can make proteins. b.) Only coding RNA can interact with the ribosome. c.) The ribosome is composed of both protein and ncRNA. d.)The ncRNA components of the ribosome behave as a ribozyme. Pick one of the FALSE statements from the 4 previous questions and explain why it is incorrect.

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