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- Can I get help please with this question? Two mutations have occurred to proteins within the glucagon signaling pathway: A) The glucagon receptor has a mutation. This mutation causes this GPCR to always have a conformation that will induce nucleotide exchange for any associated heterotrimeric G proteins, even without glucagon binding to the receptor. B) The alpha subunit of the heterotrimeric G protein has a mutation. This mutation causes the Gαarginine finger to always be in a position to properly order the catalytic residues within the Gαsubunit to promote catalysis. Question: What will the combined effect of both mutations be on the signaling pathway and what is the mechanistic reason for this effect?1117 increase in the number of passive glucose transporter on the muscle cell surface thus increases the uptake of glucose into the cell and decreases blood glucose level. Indicate whether the following conditions/practice will likely lead to diabetes (mark Yes or No). [Select] a mutation in a V-SNARE in islet cells that blocks all secretion Q Search ******* 40 ****** 99+ app.honorlock.com is CDesign a pair of primers to amplify the human Insulin gene (only the blue region) Human Insulin CDNA (gene sequence, 5'-untranslated region, 3'-untranslated region) 5'agecete agccctccaggacaggctgcatcagaagaggccatcaagcagatcactgtccttctgccATGGCCCTGTGGA TGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGACCCAGCCGCAGCCTTTGTGAACCAAC АССТСTGCGGCTCАCАCСТGGTGGAAGCTCTCТАССТАGTGTGCGGGGAACGAGGCTTCTTCTACАCACСCА AGACCCGCCGGGAGGCAGAGGACCTGCAGGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCC TGCAGCCCTTGGCCCTGGAGGGGTCCCTGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGCT CCCTCTACCAGCTGGAGAACTACTGCAACTAGacgcagcccgcaggcagccccccacccgccgcctcctgca ccgagagagatggaataaagcccttgaaccaacaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaŋ' Human insulin protein MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAEDLQVGQVELGG GPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN* 5'-C 5'-I ]-3' ]-3' Primer: I Primer: 2 I know the answers are 5'-ATGGCC-3' for primer 1 and 5'-CTAGTT-3' for primer 2 but I'm not sure why. Could some explain why?
- In Alzheimer’s disease, nerve cell death is associated with the accumulation of aggregates of misfolded protein. Compare this process with the onset of diabetes mellitus.HbA1c is used to monitor blood glucose levels because hemoglobin is the only protein in blood that is covalently modified by glucose. True False Insulin Glargine is a long-acting form of insulin that is synthesized with several D-amino acids that slow its proteolytic degradation and extend the half-life of the insulin Glargine molecule. True False"Continual addition and removal of phosphates by protein kinase and protein phosphatases is wasteful of energy-since their combined action consumes ATP-but it is a necessary consequence of effective regulation by phosphorylation" is true or false.
- Please answer the following questions 1. Give the substrate for each of the following enzymes: a. dihydrofolate reductase b. acetylcholinesterase c. lactate dehydrogenase d. DNA polymerase e. aspartate transaminaseCollagen is the main protein component of the ECM. The process of collagen synthesis is complex and it occurs intra- and extra-cellularly involving different organelles. Explain in details the collagen synthesis process. citation and references are requiard.Which one of the following statements concerning disorders of muscle metabolism presented in class is incorrect? a) Mutations in animals can spread rapidly because of line breeding to prolific males. b) The low rate of metabolism and ATP consumption in muscle and nerve makes effects of mitochondrial myopathies less observable in these tissues. c) Glycogen storage diseases resulting from mutations in glycolytic and glycogen pathway genes typically cause accumulation of abnormal glycogen and/or exercise intolerance. d) Lipid storage myopathies can result from deficiencies in enzymes of Beta-oxidation and lead to the accumulation of triglyceride droplets in muscle fibers. .
- Now answer the following questions: 1. Is this patient experiencing a disorder affecting anaerobic or aerobic metabolism? a) disorder affecting anaerobic metabolism. b) disorder affecting aerobic metabolism. c) None of them d) Both 2. You decide to perform assays to check the activity of one or more metabolic enzymes in the red blood cells. Which enzyme(s) would you check? a) Amylase b) Enzymes of pentose phosphate pathways c) Transaminase enzymes d) hexokinase, phosphofructokinase, and pyruvate kinaseIn 2-3 paragraphs (must be typed) explain: Discuss the regulation of cholesterol synthesis.Please briefly explain the ATP_modulated actomyosin cycle.