- Please answer properly QUESTION: In patients with Lesch Nyhan Syndrome, purine nucleotides are overproduced and over excreted. The hypoxanthine analogue Allopurinol, which effectively treats gout, has no effect on the severe neurological symptoms of Lesch- Nyhan patients because it does not? A. decrease de novo pyrimidine synthesis B. decrease de novo purine synthesis C. decrease urate synthesis D. increase PRPP levels (Phosphoribosyl pyrophosphate)

Principles Of Pharmacology Med Assist
6th Edition
ISBN:9781337512442
Author:RICE
Publisher:RICE
Chapter27: Medications That Affect The Nervous System
Section: Chapter Questions
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QUESTION :
In patients with Lesch Nyhan Syndrome, purine
nucleotides are overproduced and over excreted. The
hypoxanthine analogue Allopurinol, which effectively
treats gout , has no effect on the severe neurological
symptoms of Lesch- Nyhan patients because it does
not?
A. decrease de novo pyrimidine synthesis
B. decrease de novo purine synthesis
C. decrease urate synthesis
D. increase PRPP levels (Phosphoribosyl
pyrophosphate)
Transcribed Image Text:- MULTIPLE CHOICE - Please answer properly QUESTION : In patients with Lesch Nyhan Syndrome, purine nucleotides are overproduced and over excreted. The hypoxanthine analogue Allopurinol, which effectively treats gout , has no effect on the severe neurological symptoms of Lesch- Nyhan patients because it does not? A. decrease de novo pyrimidine synthesis B. decrease de novo purine synthesis C. decrease urate synthesis D. increase PRPP levels (Phosphoribosyl pyrophosphate)
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