O O O OO Activity (% Max.) Using your knowledge of aspartyl proteases, develop a plausible explanation for why protein activity changes when pH is increased or decreased from pH 4, as shown in the graph. 000 06 08 09 Hd Which statements are true? O The protein is active when one asp residue is protonated and the other is deprotonated. Both asp residues are protonated at more basic pH values. Active aspartyl proteases have only one asp residue in the active site. Only one asp side chain is protonated at low pH (below pH 3.5). Both asp side chains are deprotonated at higher pH values.

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Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
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Chapter1: Biochemistry: An Evolving Science
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Activity (% Max.)
Using your knowledge of aspartyl proteases, develop a plausible explanation for why protein activity changes when pH is
increased or decreased from pH 4, as shown in the graph.
06
08
09
10+
4.
9.
Hd
Which statements are true?
The protein is active when one asp residue is protonated and the other is deprotonated.
O Both asp residues are protonated at more basic pH values.
O Active aspartyl proteases have only one asp residue in the active site.
Only one asp side chain is protonated at low pH (below pH 3.5).
Both asp side chains are deprotonated at higher pH values.
Transcribed Image Text:Activity (% Max.) Using your knowledge of aspartyl proteases, develop a plausible explanation for why protein activity changes when pH is increased or decreased from pH 4, as shown in the graph. 06 08 09 10+ 4. 9. Hd Which statements are true? The protein is active when one asp residue is protonated and the other is deprotonated. O Both asp residues are protonated at more basic pH values. O Active aspartyl proteases have only one asp residue in the active site. Only one asp side chain is protonated at low pH (below pH 3.5). Both asp side chains are deprotonated at higher pH values.
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