Select the correct entries from the drop-down menus to complete the following sentence: Proton binding shifts the T-R equilibrium toward the state, because protons bind more tightly to the R state. Linked functions A protein exists in a conformational equilibrium between a T conformation and an R conformation. See the linked functions diagram below showing H+ dissociation from a functional group on the protein in the T conformation and the same group on the protein in the R conformation. The proton equilibrium dissociation constant depends on which conformation (T or R) the protein is in. KTR T•H* R•H* Suppose that KTH+ = 2 x 10-7 M KTH KRH* KRH+ = 4 x 10-6 M %3D KIR K'TR = 5 x 10-3 %3D T+H* R+ H* Note: The reactions are proceeding from the upper left to lower right. KTR = Equilibrium constant for T•H* -> R•H* = The [R•H*]/ [T•H*] ratio with the group protonated. K'TR = Equilibrium constant for T-> R = The [R]/[T]ratio with the group protonated. KTH+ = Equilibrium dissociation constant for proton dissociation from the T conformation. KRH+ = Equilibrium dissociation constant for proton dissociation from the R conformation.
Select the correct entries from the drop-down menus to complete the following sentence: Proton binding shifts the T-R equilibrium toward the state, because protons bind more tightly to the R state. Linked functions A protein exists in a conformational equilibrium between a T conformation and an R conformation. See the linked functions diagram below showing H+ dissociation from a functional group on the protein in the T conformation and the same group on the protein in the R conformation. The proton equilibrium dissociation constant depends on which conformation (T or R) the protein is in. KTR T•H* R•H* Suppose that KTH+ = 2 x 10-7 M KTH KRH* KRH+ = 4 x 10-6 M %3D KIR K'TR = 5 x 10-3 %3D T+H* R+ H* Note: The reactions are proceeding from the upper left to lower right. KTR = Equilibrium constant for T•H* -> R•H* = The [R•H*]/ [T•H*] ratio with the group protonated. K'TR = Equilibrium constant for T-> R = The [R]/[T]ratio with the group protonated. KTH+ = Equilibrium dissociation constant for proton dissociation from the T conformation. KRH+ = Equilibrium dissociation constant for proton dissociation from the R conformation.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
Related questions
Question
Is this the correct answer of R and T in the blanks or are they switched?
Transcribed Image Text:Select the correct entries from the drop-down menus to complete the
following sentence:
Proton binding shifts the T-R equilibrium toward the
state, because protons bind more tightly to the
R
state.
![Linked functions
A protein exists in a conformational equilibrium between a T
conformation and an R conformation.
See the linked functions diagram below showing H+ dissociation from a
functional group on the protein in the T conformation and the same
group on the protein in the R conformation. The proton equilibrium
dissociation constant depends on which conformation (T or R) the
protein is in.
KTR
T•H*
R•H*
Suppose that
KTH+ = 2 x 10-7 M
KTH
KRH*
KRH+ = 4 x 10-6 M
%3D
KIR
K'TR = 5 x 10-3
%3D
T+H*
R+ H*
Note: The reactions are proceeding from the upper left to lower right.
KTR = Equilibrium constant for T•H* -> R•H* = The [R•H*]/ [T•H*] ratio
with the group protonated.
K'TR = Equilibrium constant for T-> R = The [R]/[T]ratio with the group
protonated.
KTH+ = Equilibrium dissociation constant for proton dissociation from
the T conformation.
KRH+ = Equilibrium dissociation constant for proton dissociation from
the R conformation.](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Fcaf61854-7522-4075-8af1-447956fb28ae%2F2ad29bc5-410e-4062-908f-15e1734c91c4%2Fwpdpgg_processed.jpeg&w=3840&q=75)
Transcribed Image Text:Linked functions
A protein exists in a conformational equilibrium between a T
conformation and an R conformation.
See the linked functions diagram below showing H+ dissociation from a
functional group on the protein in the T conformation and the same
group on the protein in the R conformation. The proton equilibrium
dissociation constant depends on which conformation (T or R) the
protein is in.
KTR
T•H*
R•H*
Suppose that
KTH+ = 2 x 10-7 M
KTH
KRH*
KRH+ = 4 x 10-6 M
%3D
KIR
K'TR = 5 x 10-3
%3D
T+H*
R+ H*
Note: The reactions are proceeding from the upper left to lower right.
KTR = Equilibrium constant for T•H* -> R•H* = The [R•H*]/ [T•H*] ratio
with the group protonated.
K'TR = Equilibrium constant for T-> R = The [R]/[T]ratio with the group
protonated.
KTH+ = Equilibrium dissociation constant for proton dissociation from
the T conformation.
KRH+ = Equilibrium dissociation constant for proton dissociation from
the R conformation.
Expert Solution
This question has been solved!
Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.
Step by step
Solved in 4 steps
Recommended textbooks for you
Biochemistry
Biochemistry
ISBN:
9781319114671
Author:
Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:
W. H. Freeman
Lehninger Principles of Biochemistry
Biochemistry
ISBN:
9781464126116
Author:
David L. Nelson, Michael M. Cox
Publisher:
W. H. Freeman
Fundamentals of Biochemistry: Life at the Molecul…
Biochemistry
ISBN:
9781118918401
Author:
Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher:
WILEY
Biochemistry
Biochemistry
ISBN:
9781319114671
Author:
Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:
W. H. Freeman
Lehninger Principles of Biochemistry
Biochemistry
ISBN:
9781464126116
Author:
David L. Nelson, Michael M. Cox
Publisher:
W. H. Freeman
Fundamentals of Biochemistry: Life at the Molecul…
Biochemistry
ISBN:
9781118918401
Author:
Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher:
WILEY
Biochemistry
Biochemistry
ISBN:
9781305961135
Author:
Mary K. Campbell, Shawn O. Farrell, Owen M. McDougal
Publisher:
Cengage Learning
Biochemistry
Biochemistry
ISBN:
9781305577206
Author:
Reginald H. Garrett, Charles M. Grisham
Publisher:
Cengage Learning
Fundamentals of General, Organic, and Biological …
Biochemistry
ISBN:
9780134015187
Author:
John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson
Publisher:
PEARSON