Name (Last, First): DNA An RNA Polymerase attaches to the DNA and transcribes the DNA to mRNA Ribosone BIO 340 Activity # 1: DNA and the Central Dogma Complete: Cytoplasm Nucleus Nuclear pore ARNA Use the mRNA codon sequence and the genelic de lable in order to find the amino acid (AA) sequence of the protein. Example: if mRNA sequence is GUU then the corresponding amino acid 3-letter is Valine (Val) and the corresponding amino acid 1-letter is V DNA Coding 5 ATG| TGG ATT CTC AAG ATC AAT AGT 3¹ DNA template 3' 5' FIRST (5') LETTER mRNA codon 5' tRNA codon 3 с AA 3-letter AA 1-letter Amino acid AA - Amino acid A tRNA THE GENETIC CODE New protein being built Uuu UUC) ԼԱՔ uva) Lou (L) CUU CUC CUA CUG الالام U Pie (F) Leu (L) GUU GUC AUG Met (M) (initiator) val (M) Use numbers 1 to 3 to indicate the correct order of the flow of biological information. Translation Replication Transcription Hydroxyl group Deoxyribose sugar DNA's charge is negative due to following (circle the correct one): An alpha helix and a beta sheet in a protein are a type of (circle the correct one): Primary structure Tertiary structure SECOND LETTER ucu) UCC ACU AUC (1) ACC AUA ACA ACG Ser UCA(S) UCG CCU cee CCA COG CAU) CAC (12) C₂₂) CAG) The (T) GCU GOC Aa GCA (A) GUA GUG (tor) GCG/ Created by Dr. Susan A. Holechek for 30 340 (2022), Illustration by James Direen. Ty (Y) UAU) UAC) USA Och (terminator) UAG Amber (terminator) (H) On(Q) AAU AAC) AMA AAG) Asn (N) Lys(K) GAU) GAC GAA), GAG) Hydrogen bond Phosphate group Aup (D) GM (E) Secondary structure Quaternary structure USU) {cy (C) UGC) UGA Opa biminalar UGG Tm(W) cul CGC CGA CGG/ AGU AGC AGA) AGO DOU GOC GGA GGG Arg (R) Ser (S) Arg (R) Gay (G) UCAG с SACCAG U SCAG U с 3 А 5 THIRD (3) LETTER

Human Anatomy & Physiology (11th Edition)
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Chapter1: The Human Body: An Orientation
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**BIO 340 Activity #1: DNA and the Central Dogma**

---

**Instructions:**

Complete the table and diagram below to better understand the flow of genetic information from DNA to RNA to protein.

---

### Diagram Details:

**Nuclear Pore:**
- Allows mRNA to exit the nucleus.

**Nucleus:**
- Contains DNA, where transcription occurs.

**mRNA (messenger RNA):**
- Carries genetic information from the DNA to the ribosome.

**Ribosome:**
- Site of protein synthesis where translation occurs.

**tRNA (transfer RNA):**
- Transfers amino acids to the ribosome to be added to the growing protein chain.

**Amino Acid Chain:**
- A sequence of amino acids forms a protein.

**Important Processes:**
1. **Transcription:** DNA is transcribed to mRNA.
2. **Translation:** mRNA is translated into a protein.

---

### Table Completion:

- **DNA Coding Strand:** ATG TGG ATT CTC AAC ATC AAT AGT
- **mRNA Template:** Obtain by changing each DNA base to its complement (e.g., A to U, T to A, G to C, C to G).
- **tRNA Codon:** Match the mRNA codon with the tRNA anticodon.
- **Amino Acids (AA):** Determine the corresponding amino acid for each mRNA codon using the genetic code.

### DNA's Charge:

- **Negative Charge:** Due to the phosphate group in the DNA backbone.

### Protein Structure:

- **Alpha Helix and Beta Sheet:** Elements of a protein's secondary structure. Choose the correct type in the context.

---

### Genetic Code Chart:

**Guide:**

- Use the chart to decode the mRNA codons into corresponding amino acids.

- **First Base:** Locate the vertical column.
- **Second Base:** Locate the horizontal row.
- **Third Base:** Locate within the box.

---

**Example Exercise:**

Using the provided mRNA codon sequence, identify the amino acids, and fill in the appropriate letters using the chart.

**Note:**
The genetic code uses a 3-letter system to identify amino acids, starting with the mRNA codon from 5' to 3'. 

**Created by Dr. Susan A. Mocheks for SC 340 (2022), Illustration by James Green.**
Transcribed Image Text:**BIO 340 Activity #1: DNA and the Central Dogma** --- **Instructions:** Complete the table and diagram below to better understand the flow of genetic information from DNA to RNA to protein. --- ### Diagram Details: **Nuclear Pore:** - Allows mRNA to exit the nucleus. **Nucleus:** - Contains DNA, where transcription occurs. **mRNA (messenger RNA):** - Carries genetic information from the DNA to the ribosome. **Ribosome:** - Site of protein synthesis where translation occurs. **tRNA (transfer RNA):** - Transfers amino acids to the ribosome to be added to the growing protein chain. **Amino Acid Chain:** - A sequence of amino acids forms a protein. **Important Processes:** 1. **Transcription:** DNA is transcribed to mRNA. 2. **Translation:** mRNA is translated into a protein. --- ### Table Completion: - **DNA Coding Strand:** ATG TGG ATT CTC AAC ATC AAT AGT - **mRNA Template:** Obtain by changing each DNA base to its complement (e.g., A to U, T to A, G to C, C to G). - **tRNA Codon:** Match the mRNA codon with the tRNA anticodon. - **Amino Acids (AA):** Determine the corresponding amino acid for each mRNA codon using the genetic code. ### DNA's Charge: - **Negative Charge:** Due to the phosphate group in the DNA backbone. ### Protein Structure: - **Alpha Helix and Beta Sheet:** Elements of a protein's secondary structure. Choose the correct type in the context. --- ### Genetic Code Chart: **Guide:** - Use the chart to decode the mRNA codons into corresponding amino acids. - **First Base:** Locate the vertical column. - **Second Base:** Locate the horizontal row. - **Third Base:** Locate within the box. --- **Example Exercise:** Using the provided mRNA codon sequence, identify the amino acids, and fill in the appropriate letters using the chart. **Note:** The genetic code uses a 3-letter system to identify amino acids, starting with the mRNA codon from 5' to 3'. **Created by Dr. Susan A. Mocheks for SC 340 (2022), Illustration by James Green.**
Expert Solution
Step 1

Introduction 

Gene expression is the process through which a gene's information is used to create a functioning gene product, allowing it to produce end products like proteins or non-coding RNA and ultimately have an impact on phenotypes. While these are frequently proteins, some non-protein-coding genes, including those for transfer RNA (tRNA) and small nuclear RNA (snRNA), produce functional non-coding RNAs instead. The fundamental principle of molecular biology, which Francis Crick initially proposed in 1958, summarises gene expression.

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