Mutation 1: H to E Mutation 2: H to N Mutation 3: S to D Mutation 4: S to C

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Discuss in a short paragraph (3–5 sentences for each mutation) whether or not the enzyme is likely to completely lose catalytic activity if the following mutations are carried out. You may assume that steric effects do not distort the active site so much that catalysis cannot take place; focus your analysis on discussing the chemistry the amino acid side chains are able to perform and the properties that enable them to do so.

 

Mutation 1: H to E

Mutation 2: H to N

Mutation 3: S to D

Mutation 4: S to C

CH₂
HN
N-
H
{
HN-
R
I
CH₂
H
سمبر
HN-CHC
I
CH₂
R
||
yo
HN-CHC-
I
CH₂
R
who
N-C-C
H!
CH₂
HN-
||
HN
R
N-
H
HN-CHC
CH₂
||
độ
CH₂
-R
||
yo
HN-CHC-
I
CH₂
R
CH₂
HN-
I-Z-I
RO
CH₂
HN-
||
HN-CH-C
CH₂
R
yo
||
product removed
H₂O enters
HN-CHC
CH₂
I
OH
R
Transcribed Image Text:CH₂ HN N- H { HN- R I CH₂ H سمبر HN-CHC I CH₂ R || yo HN-CHC- I CH₂ R who N-C-C H! CH₂ HN- || HN R N- H HN-CHC CH₂ || độ CH₂ -R || yo HN-CHC- I CH₂ R CH₂ HN- I-Z-I RO CH₂ HN- || HN-CH-C CH₂ R yo || product removed H₂O enters HN-CHC CH₂ I OH R
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