Answered: (Q39) A mutation in a certain protein…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Transcribed Image Text:(Q39) A mutation in a certain protein results in the presence of a cysteine residue (rather than the normally-observed serine residue) at the active site of a protein that catalyzes a group transfer reaction. Which of the following is the most likely outcome? O There will be little no decrease in catalysis O Catalysis will stop The active site will not form O The catalytic rate will increase O The enzyme will switch over to acid-base catalysis Question 8 (Q40) The pH versus rate profile for a certain enzyme has inflection points at 2.0 and at 5.0. If the two residues in question both need to be protonated for catalysis to occur, at which of the following pH values will the the enzyme be most active? O 1.37 5.37 O Only at 2.00 and at 5.00 O 3.37 All enzymes are optimally active at physiological pH (7.40) Question 9 (Q41) Why does hexokinase not catalyze ATP hydrolysis (i.e., why does hexokinase not act on water as a substrate)?

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