Is the phosphate functional group negatively charged in both a non-cellular and cellular environment?  A better way to phrase the question: does the phosphate group ionize in a cellular environment, or does it simply stay the same?

Human Heredity: Principles and Issues (MindTap Course List)
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Chapter10: From Proteins To Phenotypes
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Problem 14QP: If phenylalanine was not an essential amino acid, would diet therapy (the elimination of...
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Is the phosphate functional group negatively charged in both a non-cellular and cellular environment? 

A better way to phrase the question: does the phosphate group ionize in a cellular environment, or does it simply stay the same? 

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