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Interpret the effect of hyperkalemia with reference to Goldman’s equation. a) What happens to rate of K+ diffusion at the MRP equilibrium with elevated extracellular [K+] (and unchanged intracellular [K+])? b) Since this diffusion rate determines the “permeability” of the cell to that K+ ion, what happens to PK+ as a result of this elevated extracellular K+? (Hint- it HAS changed.) c) Since PK+ has changed, and PNa+ is unchanged, what happens to the MRP as a result of this change in PK+? Explain with specific reference to Goldman’s equation but there is no need to cite or calculate any specific numbers, just generalize the result.

Interpret the effect of hyperkalemia with reference to Goldman’s equation. a) What happens to rate of K+ diffusion at the MRP equilibrium with elevated extracellular [K+] (and unchanged intracellular [K+])? b) Since this diffusion rate determines the “permeability” of the cell to that K+ ion, what happens to PK+ as a result of this elevated extracellular K+? (Hint- it HAS changed.) c) Since PK+ has changed, and PNa+ is unchanged, what happens to the MRP as a result of this change in PK+? Explain with specific reference to Goldman’s equation but there is no need to cite or calculate any specific numbers, just generalize the result.

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Interpret the effect of hyperkalemia with reference to Goldman’s equation.


a) What happens to rate of K+ diffusion at the MRP equilibrium with elevated extracellular [K+] (and
unchanged intracellular [K+])?
b) Since this diffusion rate determines the “permeability” of the cell to that K+ ion, what happens to PK+
as a result of this elevated extracellular K+? (Hint- it HAS changed.)
c) Since PK+ has changed, and PNa+ is unchanged, what happens to the MRP as a result of this change in
PK+? Explain with specific reference to Goldman’s equation but there is no need to cite or calculate
any specific numbers, just generalize the result. 

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