In the section dealing with “NAD+ in disease” it is mentioned that metabolomics results indicate that impaired mitochondrial function contributes to some of the mentioned diseases. Which metabolites can potentially accumulate when complex I of the electron transport chain is defective? Use Fig 1 for guidance
In the section dealing with “NAD+ in disease” it is mentioned that metabolomics results indicate that impaired mitochondrial function contributes to some of the mentioned diseases. Which metabolites can potentially accumulate when complex I of the electron transport chain is defective? Use Fig 1 for guidance
Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter18: Glycolysis
Section: Chapter Questions
Problem 9P: Comparing Glycolysis Entry Points for Sucrose Sucrose can enter glycolysis by either of two routes:...
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Question
In the section dealing with “NAD+ in disease” it is mentioned that metabolomics results
indicate that impaired mitochondrial function contributes to some of the mentioned
diseases. Which metabolites can potentially accumulate when complex I of the
electron transport chain is defective? Use Fig 1 for guidance
![Alcohol metabolism
Giycolysis
GAPDH
Lactic acid fermentation
ER
Glucose
Pyruvate
LDH Lactate
Gluconeogenesis
Lactate oxidation
(Cori cycle)
OAA
Ethanol
MDH
ADH
Malate
D5D/
D6D
PUFA
+ HUFA
Acetaldehyde
PUFA desaturation
Cytosol
Acetaldehyde
ETC
NADH
Pyruvate
ALDH
* NAD*
PDC
IMS
Acetate
Acetyl-CoA
Cyt cy
HADH
-ADP + P,
OA-
MDH
B-oxidation Acyl-COA
►ATP
LMalate
DH
TCA cycle
a-KGDH
Mitochondrial matrix](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F23d31ca4-d412-4616-b669-14f441a9818d%2Fd2812cdd-a6d1-4e57-b1d8-77891d58e743%2Fkr0a07_processed.jpeg&w=3840&q=75)
Transcribed Image Text:Alcohol metabolism
Giycolysis
GAPDH
Lactic acid fermentation
ER
Glucose
Pyruvate
LDH Lactate
Gluconeogenesis
Lactate oxidation
(Cori cycle)
OAA
Ethanol
MDH
ADH
Malate
D5D/
D6D
PUFA
+ HUFA
Acetaldehyde
PUFA desaturation
Cytosol
Acetaldehyde
ETC
NADH
Pyruvate
ALDH
* NAD*
PDC
IMS
Acetate
Acetyl-CoA
Cyt cy
HADH
-ADP + P,
OA-
MDH
B-oxidation Acyl-COA
►ATP
LMalate
DH
TCA cycle
a-KGDH
Mitochondrial matrix
Expert Solution
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Step 1
Complex I is the first enzyme of the respiratory chain. It oxidizes NADH, which is generated through the Krebs cycle in the mitochondrial matrix and uses the two electrons to reduce ubiquinone to ubiquinol. It is the largest and least understood component of the mitochondrial oxidative phosphorylation system.
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