CYP2E1 has a much higher Km for ethanol than ADH (11 mM versus 0.05 mM,respectively). When greater portions of ethanol are ingested (0.08% or 17 mM), which part of the statement would be true? CytosolMitochondrionA. PATHWAY 1.majorpathway ofethanolNAD* NADH + H*NAD* NADH + H*Hmetabolismin the liver сн, -сн, он— АDH сн, сносн, с-он + н-о-нALDHETHANOLACETALDEHYDEАСЕТАTEWATERB. PATHWAY 2microsomalethanolCYP2E1oxidizingsystem(МEOS)NADPH + H* + O2NADP* + 2H,OExcess alcohol consumption increases the NADH:NAD* ratio in the cytosol of hepatocytes.The main location of ethanol metabolism in the body is the liver and the main route ofdetoxification includes liver alcohol dehydrogenases (ADH) located in the cytosol and aldehydedehydrogenases (ALDH) located in the mitochondrion. Together these sequentially convertethanol into acetate. A second (more minor) route of detoxification includes the microsomalethanol oxidizing system (MEOS).

km that is Michaelis Menten's constant is a substrate concentration of the enzyme catalysed reaction…

Answered: CYP2E1 has a much higher Km for ethanol…

CYP2E1 has a much higher Km for ethanol than ADH (11 mM versus 0.05 mM, respectively). When greater portions of ethanol are ingested (0.08% or 17 mM), which part of the statement would be true?

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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